ANTIDIABETIC ACTIVITY OF JATROPHA GOSSYPIFOLIA LINN ROOT EXTRACTS IN ALLOXAN INDUCED DIABETIC MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Diabetes is most common endocrine disease which exists globally and interests about 6 % of the world population. The recommendation of W.H.O. about diabetes has led to a rise in investigation of medicinal plants for hypoglycemic agents. Decoction prepared from roots of Jatropha gossypifolia Linn is used in the treatment of diabetes and its associated complications. The aim of this study was to evaluate the hypoglycemic effect of successive extracts of the roots of the plant in comparison to metformin. Petroleum ether (60-80°C), chloroform, methanol and aqueous extracts (250 and 500 mg/kg body weight) were orally administered to alloxan-induced diabetic mice for 7 days. Change in body weight and plasma glucose levels were estimated after the treatment. Methanol extract exhibited significant reduction in plasma glucose level as compared to diabetic control, followed by aqueous extract. Chloroform and petroleum ether extracts were comparatively less active. The results confirm the folklore use of the plant in management of diabetes.
Authors and Affiliations
Harneet Singh , Surendra Sharma
Keywords
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