Antidiabetic, Antioxidant and Antibacterial Activities of Leaf extracts of Adhatoda zeylanica. Medic (Acanthaceae)
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
The present work is aimed at exploring the antidiabetic, antioxidant and antimicrobial activities of leaf extracts of Adhatoda zeylanica, Medic (Acanthaceae). The hexane (HE), chloroform (CE) and methanolic (ME) extracts were studied for their antioxidant and antidiabetic activities at two different doses (100mg and 200mg/kg body weight). The study of antidiabetic activity involves induction of diabetes to rats of all the groups using alloxan (100mg/kg i.p) followed by subsequent treatment with HE, CE and ME at two different doses each. The blood glucose level was then monitored by means of GOD/POD method and results were compared with standard drug glibenclamide (10mg/kg per day for one week). The antioxidant activity was evaluated using ferrozin reagent and compared with standard drug α- tocopherol. The influence of extract on cholesterol level was also evaluated using ferric chloride sulphuric acid reagents and cholesterol as standard.The antimicrobial activity was studied using various organisms by means of agar diffusion method. The extracts were found to exhibit 24% (HE), 36.2 % (CE) and 67.85 % (ME) of antioxidant activity. The two extracts were also found to decrease the blood glucose level and blood cholesterol levels significantly at same doses indicating the antidiabetic activity and the hexane extract was found to have an antibacterial activity. The result obtained confirms the antidiabetic, antioxidant and antimicrobial activities of the extracts thus making the extract more valuable in treating not only diabetes but also the associated secondary disorders.
Authors and Affiliations
Ilango K, Chitra V, Kanimozhi P, Balaji G
Keywords
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