Antidiabetic, Antioxidant and Antibacterial Activities of Leaf extracts of Adhatoda zeylanica. Medic (Acanthaceae)
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
The present work is aimed at exploring the antidiabetic, antioxidant and antimicrobial activities of leaf extracts of Adhatoda zeylanica, Medic (Acanthaceae). The hexane (HE), chloroform (CE) and methanolic (ME) extracts were studied for their antioxidant and antidiabetic activities at two different doses (100mg and 200mg/kg body weight). The study of antidiabetic activity involves induction of diabetes to rats of all the groups using alloxan (100mg/kg i.p) followed by subsequent treatment with HE, CE and ME at two different doses each. The blood glucose level was then monitored by means of GOD/POD method and results were compared with standard drug glibenclamide (10mg/kg per day for one week). The antioxidant activity was evaluated using ferrozin reagent and compared with standard drug α- tocopherol. The influence of extract on cholesterol level was also evaluated using ferric chloride sulphuric acid reagents and cholesterol as standard.The antimicrobial activity was studied using various organisms by means of agar diffusion method. The extracts were found to exhibit 24% (HE), 36.2 % (CE) and 67.85 % (ME) of antioxidant activity. The two extracts were also found to decrease the blood glucose level and blood cholesterol levels significantly at same doses indicating the antidiabetic activity and the hexane extract was found to have an antibacterial activity. The result obtained confirms the antidiabetic, antioxidant and antimicrobial activities of the extracts thus making the extract more valuable in treating not only diabetes but also the associated secondary disorders.
Authors and Affiliations
Ilango K, Chitra V, Kanimozhi P, Balaji G
Keywords
Related Articles
- EP ID EP129119
- DOI -
- Views 98
- Downloads 0
Comparative study of prescribing behaviors of government doctors of teaching hospital and private practitioners in Jhalawar City (Rajasthan)
To compare various aspects of prescribing behaviors of government doctors of teaching hospital and private practitioners. Prescription audit was conducted for a period of 2 months for out patient departments (OPDs)...
MANAGEMENT OF THE PATIENT FROM THE SITE OF ACCIDENT TO THE HOSPITAL/ PRE-HOSPITAL CARE
Pre-hospital care is very important in the emergency medical conditions and it can lead to improved patient outcomes. This pre-hospital care is usually offered to the patient on the site of incident and during transfer t...
Antibacterial and cytotoxic activity screening of leaf extracts of Vitex<br /> negundo (Fam: Verbenaceae)
The work described in this paper details the biological investigation on Vitex negundo, species of Verbenaceae. The methanol crude extract of Vitex negundo was fractionated with kupchan method and pet-ether and...
Antioxidant properties and in vitro immunomodulatory effects of peppermint (Mentha x piperita l.) Essential oils in human leukocytes
Peppermint (Mentha x piperita L.) is popular in folk medicine. Its immune effects however received so far limited attention. In the present study, peppermint oils from two cultivars (RAC 541 and Laimburg) grow...
Isolation and modification of pseudohybrid plant (Lupeol)
To start with, a brief introduction has been presented on Malaria as a serious endemic disease and the need to develop new structural classes of antimalarial agents with novel and different mechanism of action. Stress ha...