Antidiabetic potentials of Syzygium guineense methanol leaf extract
Journal Title: The Journal of Phytopharmacology - Year 2016, Vol 5, Issue 4
Abstract
This study examines the effects of a methanol extract of Syzygium guineense leaves in streptozotocin (STZ) - induced diabetes, evaluates its effect on alpha glucosidase and 2, 2-diphenyl-1-picrylhydrazyl radical. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (60 mg/kg). An oral glucose tolerance test was performed after diabetes induction and repeated after 14 days of treatment with the extract. The extract elicited antihyperglycemic action in diabetic rats evidenced by an improved oral glucose tolerance. A dose of 250 mg/kg of extract significantly (P<0.01, 0.001) enhanced glucose clearance at the end of treatment period and was comparable with metformin, the group also showed increase in hepatic glycogen content by 33.9% relative to the diabetic control. Serum biochemical analysis showed that the extract improved indices of renal and hepatic function by reduction in serum albumin, creatinine, liver enzymes, total and direct bilirubin. Similarly, the extract reduced serum cholesterol, triglycerides and high density lipoprotein (HDL) in a non-dose dependent manner; treatment with 250 mg/kg extract caused significant (P<0.05) reduction of HDL. Groups which received 250 and 500 mg/kg of extract showed reversal of glomerular damage compared with the diabetic untreated group. The extract also exhibited concentration-dependent antioxidant activity (EC50= 0.2 mg/ml) and statistically significant (P<0.01, 0.001) alpha glucosidase inhibitory effect (IC50= 6.15 mg/ml). These findings show the antidiabetic potential of S. guineense leaf extract, likely mediated through its ability to inhibit alpha glucosidase, scavenge free radicals and increase intrahepatic glucose uptake and storage.
Authors and Affiliations
Ifeoma Chinwude Ezenyi, Oluchi Joan Mbamalu, Lucy Balogun, Liberty Omorogbe, Fidelis Solomon Ameh, Oluwakanyinsola Adeola Salawu
Keywords
Related Articles
- EP ID EP49691
- DOI -
- Views 170
- Downloads 0
Effect of ethanolic extract of Reissantia indica on the human breast cancer cell line (MCF-7)
Reissantia indica belongs to the family Celastraceae, is a native shrub to Maharashtra and Bengal, India. Its distinct plant parts are said to possess different activities, natives of Maharashtra and Bengal are using th...
Phytochemical screening and cytotoxicity of selected plants used as anthelmintics in Loitoktok Sub-County, Kenya
The practice of traditional medicine is as old as the human race, and plants are an important source of research and development of new drugs. Anthelmintic resistance in human and animal pathogenic helminthes has been...
Variation in the origin of left testicular artery and drainage of right testicular vein
During routine dissection of 65 year old male Indian cadaver posterior abdominal wall, variations in the testicular vessels were observed. The left testicular artery arose from the left accessory renal artery, which or...
Endothelium-dependent and independent vasorelaxant effect of Terminalia superba (Combretaceae) on rat aorta
Terminalia superba (Combretaceae) is a plant which is used in Cameroon for the treatment of many diseases including arterial hypertension. The vasorelaxant effect of the aqueous stem bark extract of T. superba was eval...
Standardization of Haridradi churna- physicochemical assay and HPTLC profile
Haridradi churna, a polyherbal preparation containing Haridra (Curcuma longa Linn.), Devadaru (Cedrus deodar Roxb), Lodhra (Symplocos racemosa Roxb), Priyangu (Callicarpa macrophylla Vahl) and Yastimadhu (Glycyrrhiza g...