Endothelium-dependent and independent vasorelaxant effect of Terminalia superba (Combretaceae) on rat aorta
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 5
Abstract
Terminalia superba (Combretaceae) is a plant which is used in Cameroon for the treatment of many diseases including arterial hypertension. The vasorelaxant effect of the aqueous stem bark extract of T. superba was evaluated on the isolated aorta rings of the rat constricted with KCl (60 mM) or norepinephrine (10-5 M). Cumulative concentrations (20-100 µg/mL) of T. superba provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl. The maximum vasorelaxant activity of T. superba was 107.24 ± 7.01% on the intact aorta and 102.48 ± 19.09% on the denuded aorta contracted by norepinephrine. The evaluation of the effects of the aqueous extract of T. superba on the intact aorta precontracted by KCl showed a maximum relaxation of 68.43 ± 2.51% at a final concentration of 100µg/mL. The vasorelaxation induced by T. superba (100 µg/mL) on the intact aorta precontracted by norepinephrine was significantly reduced in the presence of Nw-nitro-L-arginine methyl ester (54.98 ± 6.0%, p<0.01), tetraethylammonium (58.93 ± 5.30%, p<0.05) or propranolol (69.39 ± 4.03%, p<0.05). Indometacin (10-4 M), or glibenclamide (5 µM), did not modify significantly the vasorelaxant effect of the plant extract. These results suggest that the vasorelaxation elicited by T. superba was not mediated via endothelium-derived prostacyclin or ATP-sensitive K+ channels. The direct effects of T. superba seem to be mediated by beta-adrenergic receptors and potassium channels other than potassium ATP-dependent channels. The results of this study could explain, at least partly, the use of this plant in empirical treatment of arterial hypertension.
Authors and Affiliations
Dzeufiet Djomeni Paul Désiré, Tadondjou Tchingo Cyrille D’Alex, Bilanda Danielle Claude, Aboubakar Oumarou Bibi-Farouck, Kamtchouing Pierre, Dimo Théophile
Keywords
Related Articles
- EP ID EP49526
- DOI -
- Views 251
- Downloads 0
Nephroprotective acitvity of Amomum subulatum seeds against cypermethrin induced nephrotoxicity in rats
The objective of the present study was to evaluate nephroprotective activity of Amomum subulatum seed extract against Cypermethrin induced nephrotoxicity in albino rats. The animals were divided into five different gro...
Pharmacognostic, physicochemical and phytochemical investigation of Grangea maderaspatana
Grangea maderaspatana is a popular Indian medicinal plant belonging to the Asteraceae family. This plant is commonly known as Madras Carpet. It has long been used in traditional Ayurvedic medicine for various diseases....
Evaluation of some plant extracts for nemato-toxic potential against juveniles of Meloidogyne incognita in vitro
Aqueous leaf extracts were utilized to assess the nematicidal or nematostatic property on second stage juvenile of Meloidogyne incognita. The juvenile were incubate at various concentration of leaf extract viz., 250, 50...
Physicochemical, Phytochemical and toxicity studies on gum and mucilage from plant Abelmoschus esculentus
Okra is a popular health food due to its high fiber, vitamin C, and folate content. It is also a good source of calcium and potassium. In addition, the plant has been used medicinally in the treatment of several disord...
Phytochemical screening and anticonvulsant activity of Sargassum ilicifolium (brown algae) in mice
Sargassum ilicifolium (SI) is a tropical and subtropical marine macroalgae (brown algae) found in coastal area of India. Thais study investigated the anticonvulsant activity of SI in maximal electroshock (MES) induced...