ANTIDIARRHEAL ACTIVITY OF AQUEOUS LEAF EXTRACT OF SWERTIA CHIRATA IN RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 3
Abstract
The effect of the aqueous extract of Swertia Chirata hum against diarrhea at 25,50 and 100 mg/kg body weight was evaluated by using gastrointestinal transit, diarrhea and enteropooling induced by castor oil models in female rats. The extract was positive for Ophelic acid, glycosides, amarogentin, chiratin, alkaloids, gentianine and gentiocrucine. The 25 mg/kg of the extract effectively (P<0.05) prolonged the onset time of diarrhea, decreased the fecal parameters (number, water content, fresh weight, total number of wet faces) with no episodes in the animals treated with 50 mg/kg and 100 mg/kg. The activity of small intestine Na+-k+ ATPase increased (P<0.05) while the nitric oxide, volume and mass of intestinal fluid as well as distance travelled by the charcoal meal decreased. The changing patterns were similar to reference drugs. Overall, the antidiarrheal activity of the aqueous leaf extracts of Swertia chirata hum may be due to the chemical constituents present in the extract.
Authors and Affiliations
Md. Forhad Ahmad
PERFORMANCE OF HIGH SENSITIVE TROPONIN T ASSAY IN EARLY DIAGNOSIS OF MYOCARDIAL INFARCTION
Background: High sensitive troponin T assay (hs-Tn T assay) is one of the most important tests in clinical laboratories. It is commonly used as a diagnostic test for the acute myocardial infarction. However, many health...
OUTCOME OF AUTOGENOUS VERSUS ALLOPLASTIC GRAFTS (MEDPORE) FOR RECONSTRUCTIVE AUGMENTATION RHINOPLASTY
Background: Many nasal deformities are requiring correction by augmentation rhinoplasty. Autologous and alloplastic graft materials have been used for nasal dorsal reconstruction. Objectives: This study was designed to c...
IMMUNOHISTOCHEMICAL EXPRESSION OF CANCER STEM CELL MARKER (ALDH1) IN A PROSTATE CANCER
Background: Cancer stem cells were identified in several cancers, including PCa, and have been proposed to explain the metastatic capacity, recurrence, and resistance to hormone, radio and chemotherapy in established cel...
PD‑1/PD‑L1 BLOCKADE IN METASTATIC BLADDER CANCER TREATMENT: WHAT CAN WE DO NOW FOR THE PATIENTS?
The incidence of bladder cancer (BC) is increasing and this malignant tumor is common urological malignancy in human beings. The conventional general treatment to decrease or control the tumor cells are not satisfactory,...
EVALUATION OF PHENOLICS, THE NITRIC OXIDE RADICAL SCAVENGING ACTIVITY, AND FERRIC REDUCING/ANTIOXIDANT POWEROF SALICORNIA EUROPAEA
We investigate here the antioxidant capacity in local halophytic species, Salicornia europaea,well known for their ethnopharmacological utilizations in traditional medicine.The objectives of this study were to determine...