ANTIDIARRHEAL AND ANTIBACTERIAL ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF SALVIA SCHIMPERI BENTH FROM ETHIOPIA
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 6
Abstract
In Ethiopian folk medicine, aqueous decoction of the leaves of Salvia schimperi is used for treatments of various ailments including diarrhea, however, to date, there appear to have been no reports on the phytochemistry, the antidiarrhoeal and the antimicrobial activity of the plant. In this study, the hydroalcoholic extract of the leaves of S. schimperi was evaluated for its antidiarrheal and antibacterial activities against castor oil induced diarrhea in mice and six clinically isolated enteric bacterial pathogens using standard agar diffusion methods, respectively. The minimum inhibitory concentrations (MIC) of the extracts were also determined using the microdilution method. The extract exerted significant and dose-related antidiarrhoeal activity when compared to the control and the standard drug, loperamide. The extract displayed highest antidiarrhoeal activity at a dose of 400 mg/kg which is comparable with that of the standard drug loperamide. The extract also showed moderate antibacterial effects against most of the test microorganisms except S. typhimurium. Phytochemical analysis of the extract revealed the presence of polyphenolic compounds such as flavonoids and tannins among others. The present study supports the folkloric use of the plant for the treatment of diarrhoeal diseases.
Authors and Affiliations
Shemsu Umer et al.
Keywords
Related Articles
- EP ID EP556394
- DOI -
- Views 103
- Downloads 0
A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF MICHELIA CHAMPACA LINN. FAMILY: MAGNOLIACEAE
Michelia Champaca Linn., belonging to family Magnoliaceae, is commonly known as Champa. It is a medium size evergreen tree highly distributed in eastern Sub-Himalayan tract, West Bengal, Myanmar, and South India in addit...
ANALGESIC ACTIVITY OF CINNAMALDEHYDE PER SE AND IT’S INTERACTION WITH DICLOFENAC SODIUM AND PENTAZOCINE IN SWISS ALBINO MICE.
Cinnamon is one of the best-known spices used as an herbal medicine. Cinnamaldehyde is the most important constituents of cinnamon. The present study was aimed to evaluate the analgesic activity of Cinnamaldehyde per se...
PROTECTION OF HIPPOCAMPAL AND ISLET BETA CELLS IN VITRO BY EMODIN FROM LEAVES OF RUMEX CONFERTUS
The natural anthracene derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known as an anticancer agent. In the present work it was isolated for the first time from the ethanol extract of Rumex confertus leaves...
A PHARMACOLOGICAL REVIEW: PASSIFLORA SPECIES
Plants have been the basis of many traditional medicines throughout the world for thousands of years and have continued to provide new remedies to mankind. They are one of the richest sources of bioactive compounds. The...
FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFIN BY USING DIFFERENT POLYMERS
The purpose of this research work was to develop and evaluate matrix-type transdermal patches of Ketoprofen. Employing different ratios of hydrophilic and hydrophobic polymers by a solvent evaporation technique. The phys...