FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFIN BY USING DIFFERENT POLYMERS
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 7
Abstract
The purpose of this research work was to develop and evaluate matrix-type transdermal patches of Ketoprofen. Employing different ratios of hydrophilic and hydrophobic polymers by a solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by Infrared Spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Seven formulations (Consisting of hydroxypropyl methylcellulose E5 and ethylcellulose in the ratios of10:0, 0:10, 1:9, 2:8, 3:7, 4:6, 5:5 (F1, F2, F3, F4, F5, F6, F7) were prepared. All formulations carried dimethyl sulfoxide as a penetration enhancer and dibutyl phthalate as a plasticizer in chloroform and methanol (1:1) as the solvent system. The prepared TDDS were evaluated for in-vitro release, moisture absorption, moisture loss, and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. Patch coded as F1 (HPMC alone) showed maximum release of 95.526 ± 0.982% in 8 h, whereas F2 (EC alone) showed maximum release of 67.078 ± 1.875% in 24 h and combination of polymers F7 (5:5) showed maximum release of 86.812 ± 0.262% in 24 h, emerging to be ideal formulation for Fenoprofen. The results followed Higuchi kinetics (r2), and the mechanism of release was diffusion mediated.
Authors and Affiliations
Shuwana Zakir et al.
Keywords
Related Articles
- EP ID EP556573
- DOI -
- Views 90
- Downloads 0
RHOIFOLIN: A REVIEW OF SOURCES AND BIOLOGICAL ACTIVITIES
Flavonoids are common plant constituents used extensively in phytomedicine to treat a wide range of diseases. Many pharmacological pieces of evidence suggest that flavonoids may play an important role in the decreased ri...
REGULATION OF WNT GENES IN STEM CELLS DEVELOPMENT AND ORGANOGENESIS
Stem cell biology, many signals regulated stem cells and organ development. Wnt factors play a crucial role in stem cells development and induced signaling pathway in stem cells. Wnt signals classified as a canonical and...
A COMPREHENSIVE REVIEW ON GYNURA PROCUMBENS LEAVES
Gynura procumbens (GP) commonly known as longevity spinach is one of those precious medicinal herbs of Asterceaes that are still included in an un-utilized herbs inspite of the variety of useful pharmacological propertie...
AMINO ACID ANALYSIS USING ION-EXCHANGE CHROMATOGRAPHY : A REVIEW
Amino acids are biologically active substances, and a number of them are essential for living beings. Amino acids are found in living cells as well as in body fluids of higher animals, in amounts, which vary according to...
PHARMACOGNOSTIC STUDY OF SOME MEDICINAL PLANTS USED IN GHOTI TRIBAL REGION OF NASHIK DISTRICT
World Health Organization appreciated the importance of medicinal plants for public health care in developing nations. The tribal region of Ghoti Taluka-Igatpuri, district-Nashik has various medicinal plant species to cu...