ANTIDIARRHOEL ACTIVITY OF METHANOLIC EXTRACT OF VERNONIA CINEREA (L.) LESS ON FEMALE ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
The present study was conducted with the objectives of investigating antidiarrhoel activity of Vernonia cinerea whole plant (Family-Compositae), collected from tarai region of Uttarakhand. The plant extracts were obtained via cold extraction method. For the purpose of evaluating antidiarrhoel efficacy of methanolic extract of the plant, rats were used as test animal. The time of onset of first wet faeces increased significantly and dose dependently by the extract. It was excellent at higher doses (100 & 200 mg/kg body wt., orally). It indicated reduction in peristaltic movement of gastro intestinal tract of animals. The antidiarrhoel activity was further confirmed by its significant and dose dependent decrease in number of wet faeces and number of total faeces in comparison to rats used as control.
Authors and Affiliations
Ganesh Panday , Virendra Kasana , Surendra Hore
Keywords
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