ANTIFUNGAL ACTIVITIES OF PANGIUM EDULE REINW SEED EXTRACTS INHIBIT THE GROWTH OF ASPERGILLUS FLAVUS, PRODUCER OF AFLATOXINS, THROUGH THE IN-VITRO TEST
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
Aspergillus flavus is a famous fungus that produces aflatoxins. Aflatoxins are the most well known toxic and carcinogenic chemical prominent produced in nature. The fungus and aflatoxins are the main concern of the corn consumer. Pangi (Pangium edule Reinw) is a potential native plant to reduce infestation of the fungus A. flavus to prevent fungal contamination of food or feed. The research was undertaken to assess the antifungal activity of the P. edule Reinw extracts of seed against fungus A. flavus. Higher concentration is shown as the best concentration to suppress the growth of the A. flavus both mycelial growth and emerging new colony. The concentration of the 15% effectively and consistently inhibits A. flavus than other treatments. The lower concentration of 0.5%, 0.75%, 1% showed not significantly different over the control. Another higher concentration of the 5% showed that there is no inhibition of the fungus growth. However, the concentration of the 10% indicates also as a good treatment to suppress the fungus growth. Colony appearance after 144 h after inoculation showed that concentration of 15% remains white is different than control that shows mostly green colony. This study exhibits the efficacy of formulated Pangium edule Reinw seed in inhibiting A. flavus growth.
Authors and Affiliations
A. Asman et al.
Keywords
Related Articles
- EP ID EP580645
- DOI 10.13040/IJPSR.0975-8232.10(6).2718-22
- Views 142
- Downloads 0
DETERMINATION AND APPLICATION OF BIORELEVANT DISSOLUTION MEDIA TO MEET THE IN-VIVO PERFORMANCE IN VALSARTAN AND CHLORTHALIDONE IN SOLID DOSAGE FORM
Dissolution testing with biorelevant media is used in the pharmaceutical industry as a predictive tool for the estimation of drug formulation’s in-vivo performance in bioequivalence studies. The objective of this study w...
QUINOLINE: A DIVERSE THERAPEUTIC AGENT
Quinoline and its derivatives are diverse pharmacological agents. They play a vital role in the development of new therapeutic agents. Many new therapeutic agents have been developed by using quinoline nucleus. Hence qui...
SYNTHESIS, CHARACTERIZATION, AND DNA- BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dio...
COMPARATIVE ACUTE AND SUB-ACUTE TOXICITY STUDY OF HYDRO-ALCOHOLIC EXTRACTS OF CENTELLA ASIATICA AND EVOLVULUS ALSINOIDES IN SWISS ALBINO MICE
In this study, the in-vivo toxicity of Centella asiatica & Evolvulus alsinoides were evaluated by acute and sub-acute toxicity assays according to the guidelines of OECD 423 & 407 respectively. For LD50 evaluation, a sin...
A REVIEW ON GENOTOXICITY, ITS MOLECULAR MECHANISMS, REGULATORY TESTING IN DRUG DEVELOPMENT PROCESS
Genotoxicity has fully-grown into a serious question for the cause of several cancers. In this article, we discuss the basics of genotoxicity, the chemicals which cause these genetic damages and also their mechanism of a...