QUINOLINE: A DIVERSE THERAPEUTIC AGENT
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2016, Vol 7, Issue 1
Abstract
Quinoline and its derivatives are diverse pharmacological agents. They play a vital role in the development of new therapeutic agents. Many new therapeutic agents have been developed by using quinoline nucleus. Hence quinoline and its derivatives constitute an important class of heterocyclic compounds for the new drug development. Quinoline is also known as 1-azanapthalene and many researchers have synthesized large number of quinoline derivatives. Different synthetic routes have been developed by these researchers for the synthesis of quinoline derivatives. These derivatives have also been evaluated for the relevant biological activity by in vitro as well as in vivo methods. The present review focuses on detailed work done so far on the quinoline and its derivatives in the search of new therapeutic agents. The review covers the synthesis as well as biological activities of quinoline derivatives such as antimalarial, anticancer, antibacterial, anthelmintic, antiviral, antiprotozoal, antifungal, anti-inflammatory, analgesic, cardiovascular, reproductive, central nervous system activity, hypoglycemic and miscellaneous activity.
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