Antifungal Prophylaxis In Hematopoietic Stem Cell Transplant Recipients
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2008, Vol 1, Issue 1
Abstract
Background. According to immunological deficit the period after hematopoietic stem cell transplantation (HSCT) can be divided in three phases: aplastic phase, phase of acute GVHD, and phase of chronic GVHD. Fungal infections are predominant in first, aplastic phase. Deep neutropenia and implantation of central venous catheter are two major risk factors contributing to infection. Aim. To retrospectively analyze fungal infections, fungal isolates and to compare success of different antifungal strategies during the first 30 days after HSCT. Material and methods. During a 7 year period (2000-2007), we have performed 128 HSCT in 120 patients with different hematological diseases. Male: 62 Female: 58. Median age: 34 years. Patients were treated in sterile room, conditioned with HEPA filters, and low microbes diet. Antifungal prophylaxis with Fluconazole 200mg, Itraconazole 200mg, or combination Fluconazole200/Itraconazole 200 (in high-risk patients) was administered from day 0 until day +100. Results. Patients treated with combination of Fluconazole200/Itraconazol200 have had only few oropharyngeal candidiasis, without signs of invasive fungal infection. There is no statistically significant difference between the prophylaxis with Fluconazole and Itraconazole, (p=0,302). Non-Albicans Candida is predominantly isolated funga (Non-Albicans Candida vs. Candida Albicans: 54% vs. 46%). There is no isolation of Aspergillus during the first phase after HSCT in our group of patients. Concluson. The rising incidence of invasive fungal infections and the currently problematic early diagnosis call for an intensive exploration of new drugs and further developments in diagnosis and treatment of invasive fungal infection.
Authors and Affiliations
Zlate Stojanoski| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje, Aleksandra Pivkova| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje, Sonja Genadieva-Stavrik| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje, Lidija Cevreska| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje, Milena Petrovska| Institute of Microbiology and Parazitology, Medical Faculty, University St’s Cyril and Methodius, Skopje, Republic of Macedonia, Borche Georgievski| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje
Keywords
Related Articles
- EP ID EP8587
- DOI 10.3889/MJMS.1857-5773.2008.0002
- Views 504
- Downloads 25
Macedonian Medical Master of Science (MSc) Theses Defended in 2007
A Master of Science (MSc) (Latin: Magister Scientiæ; abbreviated MSc, M.Sc., M.S. or S.M.) is a postgraduate academic master’s degree awarded by universities in a large number of countries. The degree is typically s...
Brucellosis in the Republic of Serbia – The Epizootiological Situation
Aim. To present seroprevalence data of the brucellosis in livestock in Serbia. Methods. The classical serological diagnostic methods were used: Rose Bengal (RB) for screening, Complement Fixation Test (CFT) and Indirec...
Epithelioid Angiosarcoma of the Adrenal Gland. Report of a Case and Review of the Literature
Background: Primary mesenchymal neoplasms of the adrenal gland are rare, and a malignant one is an extraordinary finding. Angiosarcomas are uncommon neoplasms and account for less than 1% of sarcomas. Due to their rari...
Premature Atrial Contractions Managed With Slow Pathway Ablation
We present data from 18 year old male patient referred to our clinic for evaluation and treatment due to persistent premature atrial contractions (PAC). Up to the time of admission, the patient never experienced paroxy...
Non-Foodborne Swine Zoonotic Diseases
The aim of this paper is to give an overview of novel swine non-foodborne zoonotic diseases that have been prominent in the last decade in swine industry. The number of swine present worldwide and the large percentage...