ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC EFFECTS OF ETHANOL EXTRACT OF NIGELLA SATIVA SEEDS IN STREPTOZOCIN / HIGH FAT DIET INDUCED HYPERGLYCEMIC MICE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 3
Abstract
Objective: The present study was designed to determine the antihyperglycemic and antihyperlipidemic effect of ethanol extract of Nigella sativa seeds, in Streptozocin/high fat diet induced hyperglycemic mice. Materials and methods: The normal serum values of glucose were determined in 40 healthy male mice before Streptozocin/high fat diet induction &at two occasions 14, 28 day after induction by Streptozocin/ high fat diet and treatment with ethanol extract of Nigella sativa seeds for 28 days, also serum C- peptide, cholesterol, triglyceride, VLDL, LDL, HDL are measured at end of experiment. Results: Nigella sativa showed decrease in serum glucose, cholesterol, triglyceride, VLDL, LDL, also increase in serum C- peptide and serum HDL level measured at day 28 compared with glyburide group also, there is improvement in MDA and GSH serum levels.
Authors and Affiliations
Alaa H. Abbas
Keywords
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