ANTIHYPERGLYCEMIC EFFECT OF BRIDELIA NDELLENSIS ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 2
Abstract
The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of B. ndellensis had no hypoglycemic effect in type 1 diabetic rats in fasting and postprandial glucose load conditions and, in type 2 diabetic rats in fasting condition. However, the extract, and its ethyl acetate and dichloromethane fractions significantly lowered blood glucose levels in type 2 diabetic rats when fed simultaneously with glucose. The active principles responsible for the antihyperglycaemic effect are concentrated in the ethyl acetate and dichloromethane fractions of the extract.
Authors and Affiliations
S. Sokeng, B. Rokeya, M. Mostafa, N. Nahar, L. Ali, P. Kamtchouing
Keywords
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