ANTIHYPERGLYCEMIC EFFECT OF METHANOL EXTRACT OF DRYNARIA QUERCIFOLIA WHOLE PLANT IN GLUCOSE-CHALLENGED MICE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 3
Abstract
Background: The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Drynaria quercifolia whole plant in glucose-challenged mice. This is a part of our ongoing anti-diabetic project to identify local plant species and plant parts which can lower blood glucose levels, Methods: Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Results: Administration of methanol extract of Drynaria quercifolia whole plant (MEDQ) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice reduced blood glucose levels by 14.6, 25.4, 31.4, and 39.4%, respectively compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 40.8%. Conclusion: Methanolic extract of whole plants of Drynaria quercifolia is effective in lowering elevated blood glucose levels, which at the highest dose tested was nearly as effective as glibenclamide.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
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