Antilactogennic Characteristics Of Methanol Extract Of Aframomum Melegueta Seed In Wistar Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
This study was designed to investigate antilactogenic characteristics of methanol extract of Aframomum melegueta seed by measuring serum concentrations of lactogenic (prolactin, estradiol and progesterone) hormones in lactating and non-lactating wister rats. A total of 18 non-lactating rats were assigned into three (3) treatments of 6 rats each. Treatment 1 and 2 (controls) received 0.11mg/kg/day of reference drug (bromocreptine) and 100mg/kg/day of Dimethylsulfoxide 1ml: 9ml of normal saline (DMSO) which is referred to as normal control in this study. Treatment 3 received 100mg/kg/day of methanol extract of Aframomum melegueta seed administered to experimental rats. Serum samples were collected and analyzed for prolaction, estradiol and progreterone by ELISA techniques. The result obtain showed a significant (P<0.05) reduction in serum concentration of prolactin for both non-lactating and lactating rats relative to normal control rats but a significant (P<0.05) increase in serum levels of the same hormones with respect to reference control drug (bromocreptine) in both non-lactating and lactating rats. Serum estradiol levels were significantly (P<0.05) reduced by methanol extract relative to normal control rats in non- lactating and lactating rats. There was however, no significant (P>0.05) changes in serum levels of estradiol relative to reference control drugs in both non-lactating and lactating rats. There was no significant (P>0.05) difference in serum levels of progesterone relative to normal control in both non-lactating and lactating rats but there was a significant (P<0.05) reduction in serum levels of progesterone in both group of experimental rats. Ability of the extract to significantly lower serum levels of prolactin and estradiol in both non-lactating and lactating rats confers on it anti-lactogenicity despite non-significant (P>0.05) changes in serum levels of progesterone.
Authors and Affiliations
H. A. Ibekwe, S. O. Akpet, P. M. Bikom
Keywords
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- EP ID EP395025
- DOI 10.9790/3008-1302063035
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