Antilactogennic Characteristics Of Methanol Extract Of Aframomum Melegueta Seed In Wistar Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
This study was designed to investigate antilactogenic characteristics of methanol extract of Aframomum melegueta seed by measuring serum concentrations of lactogenic (prolactin, estradiol and progesterone) hormones in lactating and non-lactating wister rats. A total of 18 non-lactating rats were assigned into three (3) treatments of 6 rats each. Treatment 1 and 2 (controls) received 0.11mg/kg/day of reference drug (bromocreptine) and 100mg/kg/day of Dimethylsulfoxide 1ml: 9ml of normal saline (DMSO) which is referred to as normal control in this study. Treatment 3 received 100mg/kg/day of methanol extract of Aframomum melegueta seed administered to experimental rats. Serum samples were collected and analyzed for prolaction, estradiol and progreterone by ELISA techniques. The result obtain showed a significant (P<0.05) reduction in serum concentration of prolactin for both non-lactating and lactating rats relative to normal control rats but a significant (P<0.05) increase in serum levels of the same hormones with respect to reference control drug (bromocreptine) in both non-lactating and lactating rats. Serum estradiol levels were significantly (P<0.05) reduced by methanol extract relative to normal control rats in non- lactating and lactating rats. There was however, no significant (P>0.05) changes in serum levels of estradiol relative to reference control drugs in both non-lactating and lactating rats. There was no significant (P>0.05) difference in serum levels of progesterone relative to normal control in both non-lactating and lactating rats but there was a significant (P<0.05) reduction in serum levels of progesterone in both group of experimental rats. Ability of the extract to significantly lower serum levels of prolactin and estradiol in both non-lactating and lactating rats confers on it anti-lactogenicity despite non-significant (P>0.05) changes in serum levels of progesterone.
Authors and Affiliations
H. A. Ibekwe, S. O. Akpet, P. M. Bikom
Keywords
Related Articles
- EP ID EP395025
- DOI 10.9790/3008-1302063035
- Views 97
- Downloads 0
Study on Muscle relaxing potential of Ethanolic Extract of Stem Bark of Bauhinia purpurea (L) Plant in Albino mice
Neuropharmacology is the study of how drugs effect cellular function in the nervous system, and the neural mechanisms through which they influence behavior of human beings, i.e how these drugs addiction affect the human...
Study of Nebulization with Hypertonic Saline and Other Nebulizing Agents with or With Out Antibiotics in Bronchiolitis Patients Aged 2 Months to 2 Years Admitted In RMMCH
Bronchiolitis is an acute lower respiratory tract infection that occurs in children younger than two years old. It is generally a self-limiting condition usually caused by virus. Based on this a cross-sectional prospecti...
Physiological Effects of Carbon Dioxide Treatment on Diabetic Foot Ulcer Patients
Background: Diabetic foot ulcer (DFU) considers one of the most anxious complications associated with uncontrolled diabetes mellitus. The aim of this study is to evaluate carbon dioxide therapy on patients with DFU and c...
Exploring Moringa Oleifera Usefulness In Ameliorating Induced Retinopathy In Experimental Animals
Retinopathy is a major problem of vision. It could lead to loss of vision. It is simply the degeneration of the retina. This can be as a result of assault or trauma to the eye or its retina. It can also be as a result of...
Dysphagia after anterior cervical spine surgery
.