Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 2
Abstract
Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containing ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) was used to induce hyperoxaluria in Wistar rats. Thirty-six rats, divided into following six groups (each containing six animals), were treated with vehicle (normal control), ethylene glycol and ammonium chloride (urolithic), Neeri (standard), 100, 300 and 500 mg/kg, VCE (tests). The experimental protocol involved the estimation of different biochemical parameters in urine, serum, kidney homogenates, and histopathological examinations of the kidney. Results: The urolithic rats showed the presence of oxalate crystals in renal tubules and significant changes in biochemical parameters like decreased creatinine clearance, increased urinary levels of oxalates, urea, calcium, phosphorus, uric acid, proteins, decreased urinary magnesium levels; increased serum levels of urea nitrogen, uric acid, calcium, phosphorus, lactate dehydrogenase; increased calcium, phosphorus, and oxalate contents in kidney homogenates. It altered the renal architecture and impaired the functions. The extract significantly (p< 0.05) reversed the biochemical changes in urine, serum and kidney homogenates in a dose-dependent manner. It improved the renal functions as indicated by improved creatinine clearance, reduced lactate dehydrogenase activity and restoration of renal architecture towards normal. Conclusions: Vernonia cinerea showed significant antilithiatic potential against oxalate calculi in glycolated rats.
Authors and Affiliations
Parveen Kumar Goyal, Santosh Kumar Verma, Anil Kumar Sharma
Keywords
Related Articles
- EP ID EP49728
- DOI -
- Views 192
- Downloads 0
Gastroprotective effect of ethanolic extract of Parmelia perlata in rats
Gastric ulcer disease (GUD) is one of the major gastrointestinal disorders which occur due to an imbalance between offensive (acid, pepsin and Helicobacter pylori) and defensive (mucin, prostaglandin and bicarbonate) f...
Evaluation of neuro-protective activity of Brihatvata Chinthamani Rasa
The objective of the study was to screen the neuroprotective role of Brihatvata Chinthamani Rasa, a compound mineral formulation extensively used in stroke condition in the Indian system of medicine. The selected anima...
Phytochemical analysis of Leucaena leucocephalaon various extracts
The plants play a vital role in human life. Every plant has some disease curative properties in it. Even the fodder plants have medicinal properties. In the similar way the present research was carried out to study phy...
Evaluation of antidiarrheal and antinociceptive activity of methanolic extract of Alstonia scholaris Linn. on mice models
Alstonia scholaris is an indigenous medicinal plant of Bangladesh. The leaves have been used traditionally as folk remedies for the treatment of many diseases including diarrhea, dysentery, and malaria and snake bites....
Pharmacognostic evaluation and HPTLC fingerprinting of Pirantai Vatakam, a Siddha formulation
The present study is an attempt to evaluate the pharmacognostic parameters and HPTLC fingerprint profiles for a Siddha compound formulation, Pirantai vatakam in which Cissus quadrangularis is the main ingredient. Powde...