Antimicrobial activity of amoxicillin to the pathogens of respiratory diseases in pigs
Journal Title: Біологія тварин - Year 2014, Vol 16, Issue 2
Abstract
The effectiveness of antibiotic therapy in the treatment of respiratory diseases of bacterial etiology depends on the action spectrum of antimicrobial agent and the level of susceptibility of pathogen or pathogens of disease to his actions. The aim of the study was to investigate the antimicrobial activity of β-lactam antibiotic amoxicillin against microorganisms, pathogens of respiratory diseases in pigs. For studies from pigs 2 to 4 months of age with pneumonia biological material (blood, exudate from the nasal openings) was selected. Studies were conducted with recognized microbiological methods — by diffusion in agar using standard discs with antibiotics and the method of successive serial dilutions in liquid nutrient medium. Test of antimicrobial sensitivity of biomaterial microflora showed different levels of sensitivity of microorganisms to antibiotics, which primarily explains the unlike spectrum of activity of antibacterial agents. Based on the results of the test, microflora isolated from 80 % of samples proved to be sensitive to amoxicillin. Strains of Enterococcus faecalis, Streptococcus suis and Escherichia coli were isolated and identified from biological material. Accordingly of minimum inhibitory concentration (MIC) of amoxicillin 81.25 % of isolates of enterococci, and all isolates of streptococci and E. coli were susceptible and moderately susceptible. Results of determination of MICs of amoxicillin showed that this antibiotic exhibits a high level of bacteriostatic activity in relation to the selected strains and its action spectrum covers both Gram-positive and Gram-negative bacteria. Research of sensitivity of bacteria, pathogens of pneumonia in pigs, to amoxicillin showed that this chemotherapeutic agent is antibiotic of broad-spectrum antimicrobial activity and remains the drug of choice in the treatment of swine respiratory infections of bacterial etiology caused by susceptible strains of microorganisms to amoxicillin.
Authors and Affiliations
T. I. Stetsko
Keywords
Related Articles
- EP ID EP367122
- DOI -
- Views 99
- Downloads 0
Biochemical changes in serum of chickens as a result of the action of deoxynivalenol
The article presents the results of studies of the impact of deoxynivalenol (DON) on chickens of Adler silver cross, especially on a daily and weekly body weight gain and changes in biochemical parameters of blood serum....
Growth, development and reproductive function of female rats and their offspring viability at the conditions of the watering of different doses of citrate germanium
The article presents the results of studies of the effect of citrate germanium obtained using nanotechnology and method of chemical synthesis on growth, development and reproductive function of the body of female rats an...
Study of stability of experimental living vaccine against animal anthrax with strаin UA–07 “Antravak” (18 months after production)
For the prevention of anthrax, various vaccines are developed. The article presents the results of investigations on determination of the experimental live vaccine stability against anthrax from animals of the genus Baci...
Changes in morphological parameters of peripheral blood in piglets of the first month of lives
The paper is concerned with the research of morphological parameters dynamics of peripheral blood in piglets of Large White breed, where quantitative changes of erythrocytic blood composition are recorded during the firs...
Association of single nucleotide polymorphism in the calpain/calpastatin system genes with quantitative traits of Aberdeen-Angus
Pleiotropic effect of calpain/calpastatin system genes influences both animal’s quantitative traits and qualitative characteristics of muscle tissue. The study is aimed to evaluate the association of single nucleotide po...