Antimicrobial activity of Ceftaroline and Ceftobiprole tested against MRSA isolates from Turkey, in 2016
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Ceftaroline and ceftobiprole are two new cephalosporin molecules on which intense studies have been made for the treatments of bacteria most of which are hospital infection factor, especially resistant gram positive cocci. Ceftaroline which has broad Gram-positive activity recently has been approved for clinical uses by the US Food and Drug Administration. Ceftobiprole has been approved for use in Canada and Switzerland. The objective of this investigation was to evaluate the activities of ceftaroline and ceftobiprole, against community-associated and hospital-associated methicillin-resistant S. aureus (MRSA). The activity of ceftaroline was measured in Kirby-Bauer disk diffusion method, broth microdilution method and E test for 60 MRSA isolates. The efficacy of ceftobiprole was measured in E test for 60 MRSA isolates. Ceftaroline MIC values of 51 (85%) isolates were determined as ≤1 µg/ml meaning of susceptible according to the criteria of CLSI/EUCAST and MIC values of 9 (15%) isolates were found as >1 µg/mL meaning of resistant by broth microdilution method. The range of ceftaroline MIC values of the isolates was found between 0.125-2 µg/ml. MIC50 and MIC90 values of all the isolates were determined as 0.50 µg/ml and 1 µg/ml for ceftaroline, respectively. Ceftobiprole MIC values of 60 (100%) isolates were determined as ≤2 µg/ml meaning of susceptible according to the criteria of EUCAST by E test. The range of ceftobiprole MIC values of the isolates was found between 0.125-2 µg/ml. MIC50 and MIC90 values of all the isolates were determined as 0.50 µg/ml and 1 µg/ml for ceftobiprole, respectively. The in vitro activities of ceftaroline and especially ceftobiprole against MRSA indicates that they should be a good therapeutic option for the treatment of infection caused by methicillin-resistant S. aureus.
Authors and Affiliations
Fulya Bayındır Bilman, Mine Turhanoğlu
Keywords
Related Articles
- EP ID EP383407
- DOI 10.9790/3008-11145256
- Views 84
- Downloads 0
Effect of L- Carnitine and COQ10 Addition to SMARTProMedium on Human SpermConcentration,SpermMorphology and Chromatin StructureduringIn VitroSperm Activation
This study was designed to assess the effect of different concentrations of L-carnitine and Co enzyme Q10 (COQ10) supplied to SMART Pro- medium on human sperm concentration, sperm morphology and chromatin structure durin...
A study on physico-biochemical efficiency of LBG 17 a Blackgram (Vigna mungo L. Hepper) genotype against powdery mildew
LBG 17 is a resistant inbred of Blackgram developed from susceptible parents Nethiminumu and chikkuduminumu to defend the damage due to powdery mildew. In present study the physiological efficiency of LBG 17, Nethiminumu...
Critical Analysis of Lasuna (Role of Lasuna in Different Branches of Ayurveda)
.
Dendrochronology Study of Culture Black Pine (Lat. Pinus Nigra) in Area Šumadija (Serbia)
This paper analyzes the importance of monitoring dendrochronology study as indication aspects of the vitality of trees, pine and general culture of pine. The task was processed on the basis of a detailed analysis of blac...
Effects of MM. 106 and M. 26 Rootstocks on Agromorphological Characteristics of ‘Crispin’ and ‘Granny Smith’ Apple Cultivars in Chencha, Southern Ethiopia.
This study investigated the different size determining rootstocks (MM.106 and M.26) reactions with two different apple cultivars (Crispin and Granny Smith) and their effect on vegetative growth in Chencha, Southern Ethio...