ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEWLY SYNTHESIZED BENZENE-1, 3-DIOL CONGENERS AND THEIR CHARACTERIZATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: Synthesis of novel Benzene-1, 3-diol analogues by incorporation of various aryl and hetero arylazo moieties. The newly synthesized Benzene-1, 3-diol congeners were evaluated to study their in vitro antimicrobial and antioxidant activities.Methods: This part of research work was included with the synthesis of a series of Benzene-1, 3-diol analogues by coupling of Benzene-1, 3-diol with different diazotized aryl and heteroaryl amines and their structures and physical characteristics were confirmed by different modern analytical techniques viz. FT/IR, 1H NMR, UV spectroscopy, LC-MS, DSC and elemental analysis. The in vitro antimicrobial activity of the synthesized compounds were conducted by cup and plate method against different gram positive and gram negative bacterial pathogens and fungal strains. The radical scavenging activity of the Benzene-1, 3-diol analogues were measured by DPPH method. The results of antimicrobial and antioxidant activity were statistically interpreted.Results: The newly synthesized compounds of Benzene-1, 3-diol substituted with 4-carboxy phenyl, antipyrinyl and isoxazolyl nucleus showed significant antibacterial activity. Whereas, the antipyrinyl and isoxazolyl substitued benzene-1, 3-diol analogues showed significant antifungal activities when compared with standard drugs. The Benzene-1, 3-diol analogues also exhibited effective antioxidant activity.Conclusion: This research work concluded that the newly synthesized benzene-1, 3-diol analogues posses significant antimicrobial and potential antioxidant activity.
Authors and Affiliations
Sudhir Kumar Paidesetty, Susanta Kumar Rout, Jyotirmaya Sahoo
Keywords
Related Articles
- EP ID EP578597
- DOI -
- Views 76
- Downloads 0
A RAPID VALIDATED UNI-DIMENSIONAL DOUBLE DEVELOPMENT HPTLC-DENSITOMETRY METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE, GLICLAZIDE AND PIOGLITAZONE HYDROCHLORIDE
Objective: To develop and validate a uni-dimensional double development high-performance thin layer chromatography (UDDD-HPTLC) for estimation of anti-diabetic medicine compromising of metformin (MET) gliclazide (GLZ) an...
TOPICAL BENZOPHENONE-3 MICROEMULSION-BASED GELS: PREPARATION, EVALUATION AND DETERMINATION OF MICROBIOLOGICAL UV BLOCKING ACTIVITY
Objective: Microemulsions (MEs) have been developed as active vehicles for sunscreens being physical sunscreens on their own.The aim of this study is to incorporate Benzophenone-3 (BZ-3), a chemical sunscreening agent in...
EFFECTS OF CO-TRIMOXAZOLE CO-ADMINISTRATION ON THE PHARMACOKINETICS OF AMODIAQUINE IN HEALTHY VOLUNTEERS
Objectives: Amodiaquine (AQ) is a 4-aminoquinoline antimalarial drug that is rapidly and extensively metabolized mainly by CYP2C8 enzyme to N-desethylamodiaquine (DEAQ). Co-trimoxazole (CTZ) is a combination (sulfamethox...
ISOLATION AND CHARACTERIZATION OF ENDOPHYTIC FUNGI FROM MEDICINAL PLANT CRESCENTIA CUJETE L. AND THEIR ANTIBACTERIAL, ANTIOXIDANT AND ANTICANCER PROPERTIES
Objective: The present study was aimed to isolate endophytic fungi from ethano-medicinally important plant Crescentia cujete L. in view to screen their bioactive principles towards different pharmacological applications....
A NEW NAPHTHOQUINONE ISOLATED FROM POLYGONUM MULTIFLORUM (POLYGONACEAE)
Objective: This research is mainly focused towards isolation and structural elucidation of pure compounds from the extract and fractions of Polygonum multiflorum through silica gel column chromatography.Methods: The air...