ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEWLY SYNTHESIZED BENZENE-1, 3-DIOL CONGENERS AND THEIR CHARACTERIZATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: Synthesis of novel Benzene-1, 3-diol analogues by incorporation of various aryl and hetero arylazo moieties. The newly synthesized Benzene-1, 3-diol congeners were evaluated to study their in vitro antimicrobial and antioxidant activities.Methods: This part of research work was included with the synthesis of a series of Benzene-1, 3-diol analogues by coupling of Benzene-1, 3-diol with different diazotized aryl and heteroaryl amines and their structures and physical characteristics were confirmed by different modern analytical techniques viz. FT/IR, 1H NMR, UV spectroscopy, LC-MS, DSC and elemental analysis. The in vitro antimicrobial activity of the synthesized compounds were conducted by cup and plate method against different gram positive and gram negative bacterial pathogens and fungal strains. The radical scavenging activity of the Benzene-1, 3-diol analogues were measured by DPPH method. The results of antimicrobial and antioxidant activity were statistically interpreted.Results: The newly synthesized compounds of Benzene-1, 3-diol substituted with 4-carboxy phenyl, antipyrinyl and isoxazolyl nucleus showed significant antibacterial activity. Whereas, the antipyrinyl and isoxazolyl substitued benzene-1, 3-diol analogues showed significant antifungal activities when compared with standard drugs. The Benzene-1, 3-diol analogues also exhibited effective antioxidant activity.Conclusion: This research work concluded that the newly synthesized benzene-1, 3-diol analogues posses significant antimicrobial and potential antioxidant activity.
Authors and Affiliations
Sudhir Kumar Paidesetty, Susanta Kumar Rout, Jyotirmaya Sahoo
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This article has been retracted from publication due to plagiarism
This article has been retracted from publication due to plagiarism
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