Antimicrobial Resistance Mediated through Amp C β- Lactamases
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 7
Abstract
Antimicrobial resistance is a global problem. Developing country like India is facing it more where infectious disease burden is high.Penicillins and Cephalosporins are widely used antibiotics to deal with various infections. These antibiotics have four membered β-lactam ring in it’s molecule which is essential for it’s antibacterial activity.Bacteria produce Extended spectrum β-lactamase (ESBL) which made the newer generation of antibiotics ineffective. Amp C β-lactamases are important cephalosporinases encoded on chromosomes of many Enterobacteriaceae and they confer resistance to third generation cephalosporins and β-lactamase inhibitor/ β-lactam antibiotics. Amp C β-lactamases are either chromosomally or plasmid mediated. Various phenotypic tests are used by researchers like Amp C disk test, Modified Threedimensional test, Boronic acid disk test method, Cefoxitin Agar Medium (CAM), Amp C E test, Cefoxitin Hodge test to detect Amp C β-lactamase producing organisms.Multiplex PCR is used for genotypic detection of Amp C β-lactamase. Different studies have shown Amp C β-lactamase production in E.coli, K.pneumoniae, Proteus spp., Citrobacterspp., Pseudomonasspp, Providentiaspp., Acinetobacter.Routine screening for detection of Amp C β-lactamase producing organisms should be done to avoid treatment failure and increased medical care cost.
Authors and Affiliations
Anjali Sunildatta Jog
Keywords
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