Antimicrobial Resistance Mediated through Amp C β- Lactamases
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 7
Abstract
Antimicrobial resistance is a global problem. Developing country like India is facing it more where infectious disease burden is high.Penicillins and Cephalosporins are widely used antibiotics to deal with various infections. These antibiotics have four membered β-lactam ring in it’s molecule which is essential for it’s antibacterial activity.Bacteria produce Extended spectrum β-lactamase (ESBL) which made the newer generation of antibiotics ineffective. Amp C β-lactamases are important cephalosporinases encoded on chromosomes of many Enterobacteriaceae and they confer resistance to third generation cephalosporins and β-lactamase inhibitor/ β-lactam antibiotics. Amp C β-lactamases are either chromosomally or plasmid mediated. Various phenotypic tests are used by researchers like Amp C disk test, Modified Threedimensional test, Boronic acid disk test method, Cefoxitin Agar Medium (CAM), Amp C E test, Cefoxitin Hodge test to detect Amp C β-lactamase producing organisms.Multiplex PCR is used for genotypic detection of Amp C β-lactamase. Different studies have shown Amp C β-lactamase production in E.coli, K.pneumoniae, Proteus spp., Citrobacterspp., Pseudomonasspp, Providentiaspp., Acinetobacter.Routine screening for detection of Amp C β-lactamase producing organisms should be done to avoid treatment failure and increased medical care cost.
Authors and Affiliations
Anjali Sunildatta Jog
Keywords
Related Articles
- EP ID EP431586
- DOI -
- Views 128
- Downloads 0
Study of EEG Abnormalities in Migraine
Introduction: Migraine is common disease with recurrent headache usually associated with nausea, vomiting, sensitivity to light sound or smell. Migraine without aura is common than migraine with aura. Aim: To determine a...
Genitourinary Fistulas – Our Experience
Introduction: Urogenital fistula is a physically, socially and psychologically devastating condition. Although advances occurred in the understanding of etiology, pathogenesis, diagnosis, and management, it still poses c...
Sexual Assault: a Social Dilemma Prevalence and pattern of Cases Presented at a Teaching Hospital, Lahore
Introduction: Globally, sexual assault is a heinous crime and a serious social and health problem, mostly affecting women. The situation regarding this social ailment is also alarming in Pakistan. The aim of the study wa...
A Study of Clinical and Hormonal Profile of Adult Women with Acne
Introduction: Acne is a commonly encountered condition among patients attending the dermatologists. A chronic condition of the pilosebaceous glands, it is most commonly seen among the adolescents. The acne usually remits...
Bilateral Dupuytren’s Contracture in Chronic Liver Disease
Introduction: Dupuytren’s disease is a proliferative disorder of the palmar fascia. There is proliferation of myofibroblasts and formation of nodules and fascicles within the palmar fascia. Dupuytren’s contracture has gr...