Antimicrobial Susceptibility Pattern of Haemophilus influenzae among Under-five Children Presenting at the Emergency Paediatric Unit (EPU) of Two Teaching Hospitals in Jos, Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 29
Abstract
Background: Haemophilus influenzae meningitis is a leading cause of endemic bacterial meningitis in infants and under-five children globally. H. influenza infection is severe where vaccine is not routinely used and one-third to half of the children either dies or suffers permanent disability such as deafness, paralysis or mental retardation when prompt and appropriate treatment is not instituted. Aim: This research sets to study and document the antibiotic susceptibility pattern of H. influenzae isolates from cerebrospinal fluids of under-five children presenting at the Emergency Paediatric Units of two Teaching Hospitals in Jos, Nigeria. Methodology: This was a descriptive cross–sectional prospective study conducted from October 2009 to March 2010. One hundred and sixty consecutive under-five children who presented with signs and symptoms consistent with H. influenzae meningitis were recruited. Socio-demography data was obtained with structured questionnaire. Specimens were aseptically collected and carefully processed for isolation and identification of H. influenza and subsequently the antimicrobial susceptibility pattern of the isolates. Results: The prevalence of H. influenzae meningitiswas low in Jos with prevalence of 6.3% among 160 under-five children studied, with mean age of 34 months and M: F ratio of 1:1. About 60% of these isolates were obtained from patients with acute pyogenic bacterial meningitis. Majority of the isolates were ampicillin resistant, β-lactamases producers and were all sensitive to ceftriaxone and azithromycin. Conclusion: The low prevalence of H. influenzae meningitis suggests substantial but not complete coverage of vaccine activity in this region while the susceptibility pattern of the isolate reveals and supports the vital role ceftriax one plays in the management of invasive H. influenzae infections to avoid pathologic complications.
Authors and Affiliations
Yunusa Thairu, Idris Abdullahi Nasiru, O. H. Kolade-Yunusa
Keywords
Related Articles
- EP ID EP348888
- DOI 10.9734/BJMMR/2014/10806
- Views 49
- Downloads 0
Pathophysiological Changes by Short-term Food Restriction in Obese Diabetic Rats
Aim: Reduced calorie intake by food restriction leads to extension of life span by exerting beneficial effects on metabolism. Zucker diabetic fatty (ZDF) rat is a type 2 diabetic model with obesity, showing the incidence...
Frequency of HLA-DRB1 in Iraqi Patients with Guillain-Barre Syndrome
Background: Genetic backgrounds play an important role in susceptibility to and protection against Guillain Barré Syndrome. Certain human leukocyte antigens have been found to be associated with Guillain Barré Syndrome....
Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force
Integrins are mechanoreceptors and mediate mechanotransduction by transferring forces into focal adhesions. Osteoclastogenesis starts with adhesion to the bone matrix, leading to cytoskeleton reorganization that is impor...
Association between Helicobacter pylori Infection, ABO Blood Groups and Rhesus Factor in Peptic Ulcer Disease Patients, in Gezira, Central Sudan
Blood group antigens were associated with peptic ulcer disease, which is potentially caused by Helicobacter pylori. It was recently demonstrated that the receptor for H. pylori is the blood group antigen lewisb, which is...
Parallel Screening with Papanicolaou Smear and Visual Inspection Tests Significantly Reduced False Negative Screening Results in Southern Brazil
Aims: To verify the screening performance of Pap smear and four modalities of visual inspection tests (VIT) in screening for cervical intraepithelial neoplasia CIN of grade 2, 3 or carcinoma in situ, in a low risk popula...