Antimycobacterial Activity of Benzylidene Acetone Analogues on Curcumin Against Resistant And Sensitive Mycobacterium Tuberculosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Curcumin is a compound possessing many pharmacological activities, but it has bad bioavailability and stability. Therefore modification should be conducted in curcumin structure. One of the results of curcumin analog modification is curcumin analog of Benzylidene acetone which is known as Gamavutton (GVT) series. The aim of this research is to determine the antituberculosis activity of curcumin compound analog on Benzylidene acetoneand Mycobacterium tuberculosis on sensitive strain (H37Rv). As well as determining the resistant strain (HE and SR). The anti-tuberculosis test used a method of agar dilution. The concentration used 0,125; 0,250; 0,500 and 1mg/mL; and the observation is done from the first week to the eighth week. Based on the test done, it can be seen that GVT-10 compound has an activity in inhibiting the M. Tuberculosis growth of HE and SR strains with the concentration of the media is 0,125 mg/mL
Authors and Affiliations
Cikra Ikhda Nur Hamidah Safitri, Ritmaleni . , Ning Rintiswati, Sardjiman . , Takushi Kaneko
Keywords
Related Articles
- EP ID EP250783
- DOI 10.9790/0853-1612062126
- Views 48
- Downloads 0
Morphometric variation between right and left human Tibia: A cross-sectional study in Bankura district of West Bengal.
Anthropometry is a precise method for evaluation of different measurements of dried bones and has been used as a technique to bring out regional and racial differences all over the world. Being an important anatomic unit...
A Clinicopathological & Radiological Evaluation Of Scrotal Swellings
Scrotal swellings were earlier considered to be an area over unaided clinical expertise. Scrotal swelling can occur in males at any age. Scrotal masses may be intratesticular or extratesticular, either solid or cystic.A...
Effect of Essential Phospholipids and Statin on Non Alcoholic Fatty Liver Disease in Rats Induced Periodontitis
NAFLD is the most common form of chronic liver disease, it is the hepatic manifestation of metabolic syndrome. Periodontal disease may helpfully increase the risk of progression from NAFL to NASH. Effective strategies ar...
Traumatic Tracheo-Oesophageal Fistula: A Case Study
Abstract: Traumatic tracheoesophageal fistula is a rare and potentially fatal condition. The rarity of this emergency makes it challenging to obtain exclusive clinical experience and it is also challenging to obtain firm...
Implants in Glaucoma-An Overview
Glaucoma is a multifactorial optic neuropathy in which there is a characteristic acquired loss of retinal ganglion cell and atrophy of optic nerve. Glaucoma filteration surgery (GFS) has been shown to be more effective a...