Antimycobacterial Activity of Benzylidene Acetone Analogues on Curcumin Against Resistant And Sensitive Mycobacterium Tuberculosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Curcumin is a compound possessing many pharmacological activities, but it has bad bioavailability and stability. Therefore modification should be conducted in curcumin structure. One of the results of curcumin analog modification is curcumin analog of Benzylidene acetone which is known as Gamavutton (GVT) series. The aim of this research is to determine the antituberculosis activity of curcumin compound analog on Benzylidene acetoneand Mycobacterium tuberculosis on sensitive strain (H37Rv). As well as determining the resistant strain (HE and SR). The anti-tuberculosis test used a method of agar dilution. The concentration used 0,125; 0,250; 0,500 and 1mg/mL; and the observation is done from the first week to the eighth week. Based on the test done, it can be seen that GVT-10 compound has an activity in inhibiting the M. Tuberculosis growth of HE and SR strains with the concentration of the media is 0,125 mg/mL
Authors and Affiliations
Cikra Ikhda Nur Hamidah Safitri, Ritmaleni . , Ning Rintiswati, Sardjiman . , Takushi Kaneko
Keywords
Related Articles
- EP ID EP250783
- DOI 10.9790/0853-1612062126
- Views 69
- Downloads 0
Oral Health Status among Students in Dormitories
Dental plaque is the best indicator for the oral hygiene. If we do not have satisfactory oral hygiene, there is high plaque index. DMFT index measures the prevalence of dental caries. Aim: The aim of our survey is to ass...
Patternof Urinary Calculi ata Tertiary Hospital inSubsaharanAfrica
Background: Urolithiasis is stone formation in the urinary tract which can be removed surgically to relieve symptoms or passed spontaneously in urine. They are sent to the laboratory for analyses, because knowledge of th...
Outcome Of Ankle And Subtalar Joint Arthrodesis Using Retrograde Hindfoot Fusion Nailing System A Prospective Study
Ankle and subtalar joint, when painful and refractory to conservative management, needs fusion. Fusion of both joints, known as pantalar arthrodesis (PTA) is truly a salvage procedure, an alternative to amputation. Initi...
A Case series of two patients with unusual indications for Submental orotracheal intubation
Submental intubation serves as an effective and a less invasive alternative to tracheostomy in cases where the airway is shared with surgeons and when orotracheal and nasotracheal intubation are not feasible. It has mini...
Bacteriological Profile of Neonatal Septicemia and Antibiogram of Isolates
Background: Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in first four weeks of life. It is the leading cause of neonatal mortality and morbidity in India. Aim: To...