Antimycobacterial Activity of Benzylidene Acetone Analogues on Curcumin Against Resistant And Sensitive Mycobacterium Tuberculosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Curcumin is a compound possessing many pharmacological activities, but it has bad bioavailability and stability. Therefore modification should be conducted in curcumin structure. One of the results of curcumin analog modification is curcumin analog of Benzylidene acetone which is known as Gamavutton (GVT) series. The aim of this research is to determine the antituberculosis activity of curcumin compound analog on Benzylidene acetoneand Mycobacterium tuberculosis on sensitive strain (H37Rv). As well as determining the resistant strain (HE and SR). The anti-tuberculosis test used a method of agar dilution. The concentration used 0,125; 0,250; 0,500 and 1mg/mL; and the observation is done from the first week to the eighth week. Based on the test done, it can be seen that GVT-10 compound has an activity in inhibiting the M. Tuberculosis growth of HE and SR strains with the concentration of the media is 0,125 mg/mL
Authors and Affiliations
Cikra Ikhda Nur Hamidah Safitri, Ritmaleni . , Ning Rintiswati, Sardjiman . , Takushi Kaneko
Keywords
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- EP ID EP250783
- DOI 10.9790/0853-1612062126
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