ANTINOCICEPTIVE ACTIVITY OF SRI LANKAN BLACK TEA BREW (CAMELLIA SINENSIS L.) IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
The aim of this study was to investigate the antinociceptive potential of warm black tea brew of Camellia sinensis (L.) O. Kuntze (Theaceae). This was tested in rats using high grown Sri Lankan Dust grade No: 1 black tea and four models of noceiception (tail flick, hot plate, writhing and formalin tests). Four doses of black tea brew (BTB) 84, 167, 501, 1336 mg/ml was made and orally administed to rats (N = 9/group) for testing purposes. The results showed that strong BTB possesses marked and significant (P < 0.05) antinociceptive activity having a rapid onset and a short duration of action. Further, the BTB also had profound and significant (P < 0.05) antihyperalgesic activity (in terms of carrageenan induced thermal hyperalgesic test and formalin test), in vitro antioxidant activity (DPPH method) and antihistamine activity (in terms of wheal test). The BTB-induced antinociception was blocked by nalaxone but not by atropine or metachlopramide indicating opioid receptor mediation. Further, even with subchronic administration of BTB, tolerance was not developed. It is concluded that BTB of C. sinensis has mild to moderate oral antinociceptive activity with swift onset and short duration of action which is mediated via opioid, antioxidant and antihistamine mechanisms.
Authors and Affiliations
Wanigasekara Ratnasooriya , Saminda Fernando
Keywords
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