A RANDOMISED CLINICAL TRIAL COMPARING THE EFFICACY OF OXYTOCIN INJECTION AND ORAL MISOPROSTOL TABLET IN THE PREVENTION OF POSTPARTUM HAEMORRHAGE IN MAIDUGURI NIGERIA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
To compare the effectiveness of intravenous oxytocin 10 IU and oral misoprostol tablet 600ug in the prevention of PPH. A randomised approach was used to recruit 1800 consenting pregnant women whom were randomly allocated at term to two medication groups of 10 IU oxytocin intravenously at delivery of the anterior shoulder and oral misoprostol group; 600 μg (3 x 200μg) tablets within three minutes of the delivery of baby. Blood loss by each patient was collected using precalibrated kidney dishes. Haemoglobin level was measured at term and 24 h after delivery. The study indicated higher occurrences of PPH (17.9 VS 8.9 %) and higher MBL (388.04 ± 5.910 ml VS 327.68 ± 3.953 ml) in the oxytocin medication group. Drop in the mean haemoglobin levels in the oxytocin group (0.708 ± 0.0340) was significantly (p < 0.001) higher than in the misoprostol group (0.549 ± 0.0276). The proportion of enrolees that needed additional oxytocic agents was significantly (ρ < 0.05) higher in the oxytocin group (16.4 %) than in the misoprostol group (3.6 %). None of the enrolees in either of the two medication groups had indication for blood transfusion. In Maiduguri metropolis, oral misoprostol tablet 600 μg has demonstrated better prevention of PPH than intravenous oxytocin 10 IU. The two medication approaches are safe and could be inter changed if need arises.
Authors and Affiliations
Garba Uthman , Helen Kwanashie , Abdulkarim Mairiga , Karniyus Gamaniel , Muhammed Isa , Ibrahim Abdu , Ado Geidam , Chigozie Nwaosu
Keywords
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