Antinociceptive and anti-inflammatory effects of flavonoids rich fraction of Solanum incanum (Lin) root extracts in mice
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 4
Abstract
Solanum incanum (Solanaceae) is a common perennial shrub-like herb that grows up to 0.9-1.2 m high which is a widely used as folklore remedy for ailments such as stomach-ache, headache, painful menstruation, angina, fever, sore throat and other painful conditions, sexually transmitted diseases, skin infections, burns wounds, pneumonia and rheumatism by various African communities. Crude root extracts of the herb were shown to exhibit antinociceptive and ant-inflammatory effect. In spite of all these uses of S. incanum, there’s no enough science-based information on the effect of purified extracts of the herb on these signs and symptoms. Hence the main objective of the study was to evaluating the antinociceptive and anti-inflammatory effects flavonoids rich fraction from S. incanum root in mice. In this study 6.5, 12.5 and 25 mg of flavonoids rich fraction S. incanum roots extract, diclofenac and the normal saline (vehicle) was injected subcutaneously in Swiss Albino mice 30 minutes prior to induction of pain and inflammation. Pain and inflammation were induced using dilute formalin solution that was injected in the animal’s left hind paw. The time spent in pain behavior (lifting, leaking and biting the injured paw) was measured and recorded for the first 5 minutes and between 15-30 minutes after formalin injection. Acute edema was used as an acute inflammatory model. The paw diameter was measured prior to injection with formalin and then after two hours. Significant analgesic and antiinflammatory activities (p < 0.05) were exhibited by 6.5 and 12.5 mg doses. These findings indicated S. incanum root extracts contains flavonoids with antinociceptive and inflammation effects.
Authors and Affiliations
Wambugu N. Enoc, Maina G. N. Daisy, Onyango A. Wilbroda, Wanyonyi W. Alphonse, Ngeranwa J. N. Joseph, Mwonjoria J. K. Maina
Keywords
Related Articles
- EP ID EP49835
- DOI -
- Views 188
- Downloads 0
Traditional uses, Antimicrobial potential, Pharmacological properties and Phytochemistry of Viola odorata: A Mini Review
Viola odorata Linn. is belongs to the family violaceae. It is popularly known as Sweet Violet, English Violet, Common Violet, or Garden Violet and Gulbanafsa in Hindi. V. odorata is commonly used as remedy for coughs,...
Compositional changes in sesquiterpene constituents of Blumea mollis Merr
Blumea mollis collected from different regions of Uttarakhand (India). GC and GC-MS analysis of the essential oil of these samples showed the dominance of sesquiterpenoids viz. (E)-caryophyllene, caryophyllene oxide, δ...
Comparative root anatomy and thin layer chromatographic identification of Boerhavia diffusa L. and Boerhavia erecta L.
“Punarnava” is an important rejuvenative drug, widely used in the indigenous system of medicine. The root is the officinal part and used in various formulations in Ayurveda and found two varieties in the commercial mar...
Pharmacognostical and Pharmaceutical evaluation of Herbo mineral Formulation: Aragvadhadi taila
Background: Aragvadhadi taila is a Sneha Kalpana, indicated in Kushtha Roga specially in Shvitra (Vitiligo) Roga. In present study, it has been used for external application in Shvitra (Vitiligo) Roga. Objective: Prese...
Comparative study of volatile constituents and antimicrobial activities of leaves and fruit peels of Citrus sinensis Linn
A steam distilled volatile oil from the fresh leaves of Citrus sinensis Linn. analysed by capillary-GC and GCMS yielded eight components, of which seven were monoterpenic (99.6%) and one ester (0.4%). Cis-sabinene hydra...