ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF PENTACLETHRA MACROPHYLLA AQUEOUS EXTRACTS IN MICE.
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2006, Vol 3, Issue 1
Abstract
The aqueous leaf, stem – bark, seed and fruit pericarp extracts of Pentaclethra macrophylla were examined for their cytotoxicity, while only the leaves and seeds were tested for analgesic and anti-inflammatory activities using in-vivo and in-vitro experimental models. Cytotoxicity haemagglutination assay revealed the following order of toxicity among the plant parts: fruit pericarp > stem - bark > seed > leaf with 71.4, 25.6, 5.3, and 0.5 haemagglutination titre values respectively. The extracts at 30 and 60 mg/kg exhibited analgesic activity and anti-inflammatory property using the flick and hot plate tests, acetic acid induced writhing test; and leucocyte counts, pulmonary oedema and oedema paw of mice in a dose-dependent manner. These findings therefore explain and justify ethnomedical uses of Pentaclethra macrophylla in the treatment of itching (inflammatory response) and pain in animals and in man.
Authors and Affiliations
Charles Okorie, E. Oparaocha, Clement Adewunmi, E Iwalewa, Simeon Omodara
Keywords
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