Antinociceptive Effect of Ondansetron in Albino Mice Using Acetic Acid Induced Writhing Model
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2016, Vol 5, Issue 4
Abstract
Background: Pain is an unpleasant sensory and emotional experience. Pain is a protective mechanism. Pain occurs whenever any tissues are being damaged, and it causes the individual to react and to remove the pain stimulus. Aim and Objectives: To evaluate the antinociceptive effect of ondansetron in comparison with the standard diclofenac. Material and Methods: The antinociceptive effect was tested by using the acetic acid induced writhing model in Swiss Albino mice. Animals were divided into 4 groups of 6 animals each. Animals were received distilled water (control), diclofenac (standard), ondansetron 0.5mg/kg (test I) and ondansetron 1mg/kg (test II). After 30 minutes of drug administration, 0.1 ml of 1% acetic acid was injected. Mice were placed individually into glass beakers and five minutes were allowed to elapse. They were then observed for a period of ten minutes and the numbers of writhes were recorded in each animal. The results were expressed as mean ± SEM. One way ANOVA with post-test was used for statistical calculation. Results: The numbers of writhes were 1.33±0.494 for diclofenac; 6.33±1.872 and 9.33±1.706 for ondansetron 0.5 and 1mg/kg respectively. Conclusion: Ondansetron demonstrated statistical significant antinociceptive activity at both doses (0.5mg/kg and 1mg/kg) and statistically similar effect as diclofenac.
Authors and Affiliations
Abhay Purohit, Sunil Gidamudi, Chitra Khanwelkar, Vandana Thorat, Sujata Jadhav
Effect of Body Mass Index on Postural Balance and Muscle Strength in Children Aged 8-10 years
Background: Childhood overweight and obesity, which are considered as global epidemic, can be assessed using Body Mass Index (BMI). BMI difference can lead to anatomic changes due to an increased body load. This increase...
Extranodal Non-Hodgkin's Lymphoma of Base of Tongue – Diagnosis by Fine Needle Aspiration Cytology
Waldeyer's ring is the primary site of Non-Hodgkin's Lymphoma (NHL) involvement in approximately 5 to 10% of all lymphoma patients. Of all Waldeyer's ring NHLs, the tonsil is the most frequent site,followed by the na...
A Cross Sectional Study on Knowledge, Attitude and Practice of Type 2 Diabetes Mellitus Subjects about Diabetes
Background: Strategies to improve awareness about diabetes and translation of preventive measures by innovative programmes have to be implemented at national levels to decrease the morbidity rate. Aim and Objectives: To...
Clear Cell Variant of Mucoepidermoid Carcinoma-Maxillary Region: A Case Report
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary regio...
Combined Non Transecting Anastomotic Urethroplasty with Buccal Mucosal Augmentation for the Management of Segmental Urethral Strictures – A Retrospective Study
Background: Urethral strictures are one of the common problems encountered by the urologist and affect one in 10,000 males. The aetiology can be secondary to inammation, trauma or can be idiopathic. The time honoure...