Antinuclear Antibodies Patterns in Patients with Celiac Disease
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 13, Issue 3
Abstract
Background: Celiac disease (CD) is a chronic immune-mediated disorder triggered by gluten ingestion in genetically susceptible individuals and its coexistence with other autoimmune disorders is well documented. Antinuclear antibodies (ANA) has been used as a tool for screening and following individuals with connective tissue autoimmunity. Aim: The aim of this study was to evaluate the frequency of ANA and its respective staining patterns in the serum of patients with biopsy-proven CD collected at the moment of diagnosis. Methods: Sera from 161 biopsy-proven celiac individuals (103 females; mean age 17 ± 14 years) were assayed for the presence of ANA by immunofluorescence methodology, using HEp-2 cells substrate. Results: Out of the 161 samples, 14 (8.7%) tested positive for ANA. All positive sera presented nuclear staining patterns, subdivided in three distinct groups: homogeneous nuclear, nuclear fine speckled and nuclear coarse speckled. Conclusion: CD biopsy-proven patients can present ANA positive tests. ANA test in CD individuals may be useful as a screening approach to evaluate at-risk individuals for developing other disorders or a marker of the adaptive autoimmunity in CD. The actual meaning of ANA positivity among CD individuals is yet to be understood.Celiac disease (CD) is a chronic multisystem disorder triggered by gluten ingestion in genetically susceptible individuals [1,2]. The intestine is the primary affected site. Typical lesions are characterized by increased intraepithelial lymphocytes, crypt hypertrophy and progressive villous atrophy [3,4] resulting in malabsorption, diarrhea, bloating and to variable degrees of undernutrition. Although triggered by a dietary antigen, it shows many autoimmune characteristics, such as the presence of high titers of anti-tissue transglutaminase 2 autoantibodies produced in the small intestinal mucosa [5]. Similar to other autoimmune disorders, CD has a higher prevalence in females, with a female: male ratio of 2:1. It has been suggested that lengthier exposure to gluten in celiac patients may increase the risk of other autoimmune diseases, i.e., the more advanced is the patient’s age at CD diagnosis, the higher would be the chance of presenting or developing another autoimmune disorder [6,7]. However, older age at diagnosis may be a bias since the prevalence of some autoimmune diseases and also CD tend to increase with aging [8,9].
Authors and Affiliations
Rosane Mansan Almeida, Zita Dinis Lopes da Silva, Franco Batista Leite, Yanna Karla de Medeiros Nóbrega
Keywords
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- EP ID EP585813
- DOI 10.26717/BJSTR.2019.13.002418
- Views 197
- Downloads 0
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