Antioxidant Activity of Some Nigerian Medicinal Plants Used in Malaria Treatment
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 1
Abstract
Received 17 November 2017 Revised 06 December 2017 Accepted 22 December 2017 Published online 07 January 2018 Free radicals are reactive molecules associated with many diseases including malaria; causing complications. Thus, the need to explore compounds with free radical scavenging properties. Methanol extracts of the leaves of three medicinal plants (A. barteri, O. basilicum and H. indicum) used in Nigerian folkloric medicine for the treatment of malaria were evaluated for their antioxidant activty, total phenol and flavonoid contents. The antioxidant activity evaluation included various radicals or oxidation systems - ferric-reducing antioxidant power (FRAP), 2, 2'azinobis-(3-ethylbenzthiazoline-6-sulfonate) radical (ABTS), and oxygen radical absorbance capacity (ORAC) assays. Total phenol and flavonoid contents were also evaluated. The leaves of A. barteri showed the highest levels of total phenol (222.30 ± 5.48 mg gallic acid equivalent/g), flavanol (22.90 ± 0.15 mg catechin equivalent/g) and flavonol contents ( 93.32 ± 2.80 mg quercetin equivalent/g) compared to O. basilicum and H. indicum. The antioxidant activity of these plants increased with increase in their total phenol and flavonoid contents. The order of the antioxidant activity of the plants was A. barteri > O. basilicum > H. indicum. These results suggest that the leaves of these plants contain polyphenols and could serve as potential sources of antioxidants which could be explored as therapeutic agents in the attenuation of free radical in malaria infection.
Authors and Affiliations
Oluwafunke O. Oribayi, Mbang A. Owolabi, Grace E. Ukpo, Francis O. Shode
Keywords
Related Articles
- EP ID EP489335
- DOI 10.26538/tjnpr/v2i1.4.
- Views 82
- Downloads 0
Determination of Optimum Composition of Fermentation Medium for Citric Acid Production from Watermelon Rinds using Response Surface Methodology
A four variable Box-Behnken design (BBD) coupled with response surface methodology (RSM) was employed to optimise the composition of fermentation medium for the production of citric acid from watermelon rind using Asperg...
The Role of Metallothionein and Some Micronutrients in the Pathogenesis of HIV Infection: A Review
Received 12 June 2018 Revised 25 June 2018 Accepted 27 June 2018 Published online 08 July 2018 Human immunodeficiency virus (HIV) infection remains a major public health challenge especially in sub-Sahara Africa where t...
Antidepressant Activity of Ethanol Extract and Residual Aqueous Fraction of Carissa edulis (Apocynaceae) Root Bark in Mice
Carissa edulis (Vahl) (family, apocynaceae) is used traditionally for the management of headache, chest pain, gonorrhea, rheumatism, epilepsy and some mental illness. This study was aimed at evaluating the antidepressant...
Modulation of Cytokines by Ketogenic Diet and Cyclophosphamide Chemotherapy in 1-Methyl Nitrosourea-Induced Mammary Tumour in Rats
Received 02 November 2018 Revised 17 November 2018 Accepted 24 November 2018 Published online 27 November 2018 Cancer is the second leading cause of death worldwide and it is expected to increase fivefold in the next 25...
An Overview of Ethnoveterinary Medicine in Nigeria
A myriad of animal diseases are responsible for major losses in livestock production, threatens the epidemiology, control and prevention of zoonosis and pose a major threat to human health and as constraints to the devel...