Antioxidant and Anti-Inflammatory Activity of ArthrospiraplatensisVar. Lake Chad
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 8
Abstract
Abstract:The objective of this study is to evaluate the antioxidant and anti-inflammatory activity of the aqueous extract of Arthrospiraplatensis var. Lake Chad, also call spirulina. A phytochemical screening of the aqueous extract was done for the characterization of the secondary metabolites. The microbiological quality was estimated and essays of acute toxicity were made. The anti-inflammatory activity was determined by the method of the oedema led by carrageenan; total phenols were determined and the antioxidizing activity was estimated by the method of trapping of the radicals free of the DPPH. The phytochemical test showed the presence of tannins, flavonoids, sterols, saponosides and alkaloids. Subsequently, during the microbiological quality control, no presence of total coliforms, fecal coliforms, molds and salmonella was observed. As well as during the test of acute toxicity, no behavior disorder, no death was observed, even at the highest orally dose tested of 5000 mg/kg (DL˃ 5000 mg/kg). For the anti-inflammatory effect, the doses of 250 and 500 mg / kg of aqueous Arthrospiraplatensis extract were administered to the rats. After injection of carrageenan under the plantar aponeurosis of the right posterior paw of the rat, paw edema was measured at first at 30 minutes, then every hour during 5 hours, using a caliper. The results showed a significant dose-dependent reduction in paw diameter (p <0.05), with inhibition percentage of 20.45% and 31.92%, respectively. These effects are comparable to that of dexamethasone which is a reference anti-inflammatory drug. The dosage of total phenols of aqueous extract revealed a content in total phenols of 0.647 mg EAA/g ES. The antioxidant activity of the aqueous extract showed a trapping effect on the DPPH radical with an IC50 = 0.056 mg / ml. These values are comparable to those of the reference antioxidant (ascorbic acid).The obtained results demonstrated that Arthrospiraplatensis var. Lake Chad aqueous extract possesses an anti-inflammatory and antioxidizing activity. These properties can be used in the prevention of the inflammatory diseases and that relating to oxidative stress.The results obtained showed that the aqueous extract of Arthrospiraplatensis var. Lake Chad has an anti-inflammatory and antioxidant activity. These properties can be used in the prevention of the inflammatory diseases and that relating to oxidative stress. Keywords: Anti-inflammatory, antioxidant, Arthrospiraplatensis, Lake Chad.
Authors and Affiliations
EtameLoe Gisèle, Dibong Siegfried Didier
Keywords
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