The antioxidant properties of1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-onederivatives under conditions of artificial oxidative stress in vitro
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 1
Abstract
Abstract: Experimental pharmacological researchof 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one derivatives.Determination of the nature of the effect of electron-donating and electron-withdrawing substituents in the phenyl fragment of the molecule on expression of the antioxidant activity.Analysis of some aspects of the "structure–activity" relationship.Derivatives of1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one were synthesized by Hantzsch method. Experimental pharmacological research was carried out on the model of artificial oxidative stress using the emulsion of egg-yolk lipoproteins in vitro as a substrate of oxidation. The substances of group 1 with methyl substituents and group 2 with chlorine substituent posseses pronounced antioxidantactivity. The substances of group 2 with methoxy substituentposseses moderate antioxidantactivity. Introduction of any substituents leads to a significant change in the level and direction of antioxidant activity of the substances; and it depends on the chemical nature and orientation of the substituents in the phenyl fragment of the molecule.Among the compounds under research four compounds can be recommended as potential antioxidants for further screening studies. Keywords: 1,3-thiazole derivatives, in vitro, artificial oxidative stress, antioxidant activity
Authors and Affiliations
Lina Perekhoda, Hanna Yeromina, Irina Drapak, Natalia Kobzar, Olexandr Smolskiy
Keywords
Related Articles
- EP ID EP389271
- DOI -
- Views 102
- Downloads 0
Retro-Lunar Dislocations: About 12 Cases
The retro-lunar carpal dislocations are often under-diagnosed in the emergency services by the lack of knowledge of the pathology. The modalities of taking care of the lunations are still discussed; if the surgical treat...
Formulation and Evaluation of Gastroretentive Floating Matrix Tablets of Metronidazole using a Novel Non-effervescent Technique
Abstract:The aim of this study was to formulate a novel non-effervescent gastro-floating drug delivery system of metronidazole using non-effervescent (sublimation and sintering) technique. Granules were prepared by wet g...
Effects of STZ-Induced Long-Term Hyperglycemia on the Lumbar Dorsal Gray Column of Albino Rats- A Histomorphometric Study
Abstract:One of the common clinical observations regarding long-standing diabetes is peripheral neuropathic pain, probably due to its destructive effects on the pain modulating neurons of the dorsal gray column of the sp...
Knowledge on Preconception Care among Reproductive age Women
Abstract: Preconception care is any intervention provided to women and couples of childbearing age, regardless of pregnancy status or desire, before pregnancy, to improve health outcomes for women, newborns and children....
Indomethacin Induced Toxicity: A Biochemical Study in Male Wistar Albino Rats
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) which acts as an analgesic and antipyretic drug. This research work was aimed at demonstrating the effects of oral administration of indomethacin on some bioc...