Antioxidant and Antitumor Activities on Catunaregum spinosa.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 3
Abstract
The methanol extract of Catunaregum spinosa (MECS) were evaluated for antitumor activity and antioxidant activity against Dalton’s ascites lymphoma (DAL) bearing Swiss albino mice. The extract was administered at the doses 200 and 400mg/kg body weight per day for 14 days after 24h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of DAL-bearing hosts, hematological profile, biochemical and antioxidant profile. MECS caused significant decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of DAL-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The lipid peroxidation was increased in tumor bearing animals, after treatment with MECS antioxidant levels increased significantly. The results indicate that MECS exhibited significant antitumor activity in DAL-bearing mice.
Authors and Affiliations
A. Chitra A. Chitra
Keywords
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