Ulceroprotective effect of ethanolic extract of aegle marmelos leaves in wistar rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 1
Abstract
Title Ulceroprotective effect of ethanolic extract of Aegle marmelos leaves in wistar rats.. Objectives To evaluate the Ulceroprotective effect of ethanolic extract of Aegle marmelos leaves in wistar albino rats. Materials & Methods The study was conducted in 24 male adult wistar albino rats weighing 150-200g. 24 rats were randomized into 4 groups and ulceroprotective property of the extract was studied employing indomethacin induced ulcer model. Groups 1 & 2 were the normal and ulcer control respectively .Groups 3 and 4 were pretreated with misoprostol and extract (200mg/kg) respectively for 5 days followed by ulcer induction in groups 2, 3 and 4. Ulceroprotective activity was expressed as Percentage inhibition (PI). Statistical analysis was performed by one-way ANOVA followed by Tukey’s post-hoc test for multiple comparisons. p < 0.05 was considered to indicate statistical significance. Results The result data indicated that, mean ulcer index was significantly lower in the leaf extract pretreated group [Group 4 (5.175±0.05)] compared to control group with a PI of 50%. Histopathological examination confirmed the ulceroprotective activity of the extract evident from the reduction in number and severity of gastric ulcers Conclusion Based on the above findings it can be inferred that ethanolic extract of Aegle marmelos leaf extract has ulceroprotective property and pretreatment of the extract is beneficial in prevention of gastric ulcer.
Authors and Affiliations
Saranya R
Keywords
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