Antioxidant and Cytoprotective Action of Aqueous Extract of Citrus Sinensis Fruit Peel against Endosulfan Induced Damage on Saccharomyces Cerevisiae
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2016, Vol 4, Issue 1
Abstract
In this study aqueous extract of Citrus Sinensis fruit peel was investigated with different antioxidant assays and cytoprotective action on xenobiotic induced oxidative stress in Saccharomyces Cerevisiae (yeast cells) was examined. The results showed that the aqueous extract showed protective effect in scavenging free radicals that were generated with different in vitro models with IC50 of 0.2 mg/ml on DPPH, 0.36 mg/ml on lipid peroxidation, 0.41 mg/ml in superoxide anion and also good activity in reducing power. Further the extract showed cytoprotective effect on xenobiotic induced (endosulfan) oxidative stress in yeast cells. The parameters that were studied in yeast cells were cell viability, reactive oxygen species (ROS), lipid peroxidation (TBARs), and lactate dehydrogenase leakage (LDH). Extract along with xenobiotic showed significant cytoprotective effect compared to that of xenobiotic induced cells alone this study shows that Citrus Sinensis fruit / peel can be consumed in our daily diet for boosting the immune system, which can minimize the free radical damage caused due to various oxidative stress
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