Antioxidant and Hepatoprotective Activities of Carica papaya (Papaw Leaf) and Loranthus bengwensis (Cocoa Mistletoes) against Diclofenac Induced Hepatotoxicity in Rats
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 5
Abstract
In this study, the effect of diclofenac sodium induced liver damage in rats was investigated, biochemically. Damaging effects of reactive oxygen species (ROS) on living systems are well documented, they include oxidative attack on vital cell constituents. Administration of diclofenac sodium at different concentrations (50 mg/kg, 100 mg/kg, and 150 mg/kg/d) for 14 days produced severe liver injury, as demonstrated by dramatic elevation of plasma hepato specific markers like aspartate amino transaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). In addition, diclofenac sodium administration caused oxidative stress in rats, as evidence by increased ROS production and malondialdehyde (MDA) concentrations in the liver of rats, along with a remarkable reduction in hepatic catalase (CAT) activity. However, simultaneous treatment with aqueous extract of dry pawpaw leaf (30%) and cocoa mistletoes (30%) significantly attenuated diclofenac sodium induced hepatotoxicity. The results showed that serum marker enzymes and hepatic MDA content as well as ROS production were reduced dramatically and CAT activity content were restored remarkably when treated with the extracts, as compared to the diclofenac sodium treated rats. It is, therefore suggested that dry pawpaw leaf and cocoa mistletoes employed in this study can provide a definite protective effect against acute hepatic injury caused by diclofenac sodium in rats, which may mainly be associated with its antioxidative effect.
Authors and Affiliations
Oseni OA, Odesanmi EO, Oloyede OI, Adebayo OD, Ogundare MAB
Keywords
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- EP ID EP671096
- DOI 10.21276/ijlssr.2018.4.5.3
- Views 81
- Downloads 0
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