Antioxidant, anti-alpha-glucosidase and pancreatic beta-cell protective effects of methanolic extract of Ensete superbum Cheesm seeds

Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 2

Abstract

Objective: To investigate the antioxidant, anti-a-glucosidase and pancreatic b-cell protective potential of Ensete superbum (E. superbum) seeds. Methods: A variety of in vitro assays including radical scavenging, reducing power potential, phenolic content determination, a-glucosidase assay and pancreatic b-cell (1.4E7 cells) viability were employed for assessing the effect of methanolic extract of E. superbum seeds. Results: The radical scavenging and reducing power effects comparable with the standard rutin were obtained while the enzyme inhibitory activity of the extract was 68-fold better than the standard antidiabetic drug, acarbose. The seed extract of E. superbum was packed-full of polyphenols with mean percentage gallic acid equivalent value of (38.2 ± 1.8) (n = 3). The protection of pancreatic cells from massive onslaught of hydrogen peroxide was far superior to that obtained for rutin. Conclusions: The reputed antidiabetic therapeutic uses of the seeds extract of E. superbum may be justified on the basis of inhibition of carbohydrate enzymes, antioxidant effects and pancreatic b-cell protection.

Authors and Affiliations

Solomon Habtemariam, George Kabakasseril Varghese

Keywords

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  • EP ID EP247906
  • DOI 10.1016/j.apjtb.2016.10.012
  • Views 99
  • Downloads 0

How To Cite

Solomon Habtemariam, George Kabakasseril Varghese (2017). Antioxidant, anti-alpha-glucosidase and pancreatic beta-cell protective effects of methanolic extract of Ensete superbum Cheesm seeds. Asian Pacific Journal of Tropical Biomedicine, 7(2), 121-125. https://europub.co.uk/articles/-A-247906