Antioxidant capacity of N’-méthylferrocényl-N'-phénylaceto-hydrazide and determination of binding parameters with superoxide anion radicals and 2,2-diphenyl-1-picrylhydrazyl
Journal Title: PhytoChem & BioSub Journal - Year 2019, Vol 13, Issue 1
Abstract
The antioxidant activity of N’-méthylferrocéyl-N'-phénylaceto-hydrazide was surveyed utilizing spectrophotometrical and electrochemical technics. We used 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) for the Spectrophotometrical measures and the cyclic voltammetry assays were supported activity by measuring the reaction peak current of comparatively stable superoxide (O2°- ) electrochemically produced by reduction of commercial molecular oxygen in DMF. The interaction of ferrocene derivative N'-ferrocenylmethyl-N’- phenylacetohydrazide with DPPH and O2°-appears good radicals scavenging activities (0.03787 and 1.22 mg/ml) severally that was considerably nearer to that of standard antioxidant ascorbic acid. The diffusion coefficients of the free and O2°-bound forms of N’-ferrocenylmethyl-N’-phenylacetohydrazide were assessed from Randles-Sevcik equation. Cyclic Voltammetry based tests were created for the calculation of binding parameters like binding constant, the proportion of binding constants and binding free energy
Authors and Affiliations
MOUADA H, LANEZ T
Keywords
Related Articles
- EP ID EP614034
- DOI -
- Views 15
- Downloads 0
Antioxidant, antimicrobial and anti-inflammatory activities development of methanol extract of Saxifraga veronicifolia Pers
Plant secondary metabolites are excellent candidates for developing new phytopharmaceuticals. Hence, the biological potentials development of Saxifrage veronicifolia extract was evaluated using antioxidant activity (DPPH...
Ethnobotany of the spontaneous medicinal flora of an extreme environment (rock of salt) of the region of Djelfa-Algeria
This study was conducted with the objective of inventorying the spontaneous species found in an extreme "rocket of salt" environment of the Algerian steppe and to collect information on the ancestral know-how of the loca...
Synthesis and Comparative Spectroscopic Characterization of N-Protected Amino Esters, Bioactive
Methyl (pyridin-2-ylmethyl) phenylalaninate and methyl benzylphenylalaninate were prepared by reaction of the phenylalanine methyl ester with bromobenzyl bromide and bromomethylpyridine derivatives The carbon-nitrogen bo...
Optimization of the reducing power for antioxidant activity test and application on two medicinal plants
The aim of this work is to determine a long-term survival as the optimization of the reducing power for antioxidant activity test and application on two medicinal plants; Zilla macroptera and Bubonium graveolens. A new p...
Effects and phytotherapeutic properties of Artemisia vulgaris, Urtica dioica, Marrubium vulgare, Thymus hyssopus, and Aloysia triphylla on geneto-urinary diseases
Medicinal plants of natural origin, potentially antimicrobial led us to look at bioactive molecules of plants from African biodiversity for the synthesis of drugs or pharmaceutically active compounds. The objective of th...