Antioxidant capacity of N’-méthylferrocényl-N'-phénylaceto-hydrazide and determination of binding parameters with superoxide anion radicals and 2,2-diphenyl-1-picrylhydrazyl
Journal Title: PhytoChem & BioSub Journal - Year 2019, Vol 13, Issue 1
Abstract
The antioxidant activity of N’-méthylferrocéyl-N'-phénylaceto-hydrazide was surveyed utilizing spectrophotometrical and electrochemical technics. We used 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) for the Spectrophotometrical measures and the cyclic voltammetry assays were supported activity by measuring the reaction peak current of comparatively stable superoxide (O2°- ) electrochemically produced by reduction of commercial molecular oxygen in DMF. The interaction of ferrocene derivative N'-ferrocenylmethyl-N’- phenylacetohydrazide with DPPH and O2°-appears good radicals scavenging activities (0.03787 and 1.22 mg/ml) severally that was considerably nearer to that of standard antioxidant ascorbic acid. The diffusion coefficients of the free and O2°-bound forms of N’-ferrocenylmethyl-N’-phenylacetohydrazide were assessed from Randles-Sevcik equation. Cyclic Voltammetry based tests were created for the calculation of binding parameters like binding constant, the proportion of binding constants and binding free energy
Authors and Affiliations
MOUADA H, LANEZ T
Keywords
Related Articles
- EP ID EP614034
- DOI -
- Views 33
- Downloads 0
Synthesis of biaryls via palladium-catalyzed cross-coupling reactions
The biaryl moiety, a molecular structure commonly encountered in organic chemistry, is present in many natural products or synthetic substances of biological and pharmaceutical interest.The various modes of obtaining bia...
Antioxidant, antimicrobial and anti-inflammatory activities development of methanol extract of Saxifraga veronicifolia Pers
Plant secondary metabolites are excellent candidates for developing new phytopharmaceuticals. Hence, the biological potentials development of Saxifrage veronicifolia extract was evaluated using antioxidant activity (DPPH...
Hepatotoxicity of squirting cucumber. Zoom on a phytotherapy in Algerian society
Herbal medicine occupies an important place among the disciplines of medication used in many societies including Algerian society. However, the danger of its use, often underestimated, poses health problems. Hepatotoxici...
Antioxidant and antimicrobial activities of aqueous extract of Linaria simplex DC.
Linaria simplex DC., is an annual or hardy plant wide represented in Algeria. Tested for their antioxidant and antimicrobial activities. Antioxidant properties were evaluated through the ability of the extract to scaveng...
Synthesis and Comparative Spectroscopic Characterization of N-Protected Amino Esters, Bioactive
Methyl (pyridin-2-ylmethyl) phenylalaninate and methyl benzylphenylalaninate were prepared by reaction of the phenylalanine methyl ester with bromobenzyl bromide and bromomethylpyridine derivatives The carbon-nitrogen bo...