Antioxidant capacity of N’-méthylferrocényl-N'-phénylaceto-hydrazide and determination of binding parameters with superoxide anion radicals and 2,2-diphenyl-1-picrylhydrazyl
Journal Title: PhytoChem & BioSub Journal - Year 2019, Vol 13, Issue 1
Abstract
The antioxidant activity of N’-méthylferrocéyl-N'-phénylaceto-hydrazide was surveyed utilizing spectrophotometrical and electrochemical technics. We used 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) for the Spectrophotometrical measures and the cyclic voltammetry assays were supported activity by measuring the reaction peak current of comparatively stable superoxide (O2°- ) electrochemically produced by reduction of commercial molecular oxygen in DMF. The interaction of ferrocene derivative N'-ferrocenylmethyl-N’- phenylacetohydrazide with DPPH and O2°-appears good radicals scavenging activities (0.03787 and 1.22 mg/ml) severally that was considerably nearer to that of standard antioxidant ascorbic acid. The diffusion coefficients of the free and O2°-bound forms of N’-ferrocenylmethyl-N’-phenylacetohydrazide were assessed from Randles-Sevcik equation. Cyclic Voltammetry based tests were created for the calculation of binding parameters like binding constant, the proportion of binding constants and binding free energy
Authors and Affiliations
MOUADA H, LANEZ T
Keywords
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