Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
The antitumor effect of hydrogen nanobubble was evaluated in vitro and in vivo. Cancer cell growth was inhibited in the hydrogen nanobubble-containing medium compared to the non-containing medium (in vitro). Tumor growth was significantly suppressed in the middle stage of transplantation (in vivo). We reported that hydrogen nanobubbles is a ROS scavenger, therefore apoptosis due to ROS reduction may be induced in these results. Hydrogen is known to have a strong antioxidant effect, derived by its high reducing property [1]. However, hydrogen is difficult to dissolve in water. Thus, an exclusive device is required to generate the hydrogen water [2,3]. To clear this problem, we investigated the stable supply of hydrogen by nanobubbes. In our previously report, hydrogen nanobubbles eliminated the superoxide as compared to other gases in cell-free systems [4]. In this study, we examined the effect of hydrogen nanobubbles on cancer growth in vitro and in vivo.
Authors and Affiliations
Hiromi Kurokawa, Hirofumi Matsui, Hiromu Ito, Atsushi Taninaka, Hidemi Shigekawa, Gjergj Dodbiba, Yuezhou Wei, Toyohisa Fujita
Keywords
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- EP ID EP622755
- DOI 10.26717/BJSTR.2019.19.003361
- Views 185
- Downloads 0
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