Antioxidant Effects of Nigella Sativa in the Treatment of Experimentally Induced Rhinosinusitis
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 2
Abstract
Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into control, NS 50, NS 100 and NS 200 mg/kg/d groups. NS was given orally for 7 days. The same volume of normal saline was given as a vehicle to the control group for the same period. At 7 days post-treatment, mucosal samples were excised from the treated and control groups for measurements of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO) and malondialdehyde (MDA). Results. SOD and GSH-Px activities significantly increased in the NS 50, NS 100 and NS 200 mg/kg/ d groups when compared with the saline treated group. MPO activity and MDA levels significantly decreased in the NS 50, NS 100 and NS 200 mg/kg/d when compared with the saline treated group. Conclusion. These findings show that administration of NS increased the SOD, GSH-Px activities and decreased the lipid peroxidation and MPO activity in experimental rhinosinusitis in rabbits. NS prevented oxidative stress by scavenging reactive oxygen species generated in rhinosinusitis model in rabbits.
Authors and Affiliations
Ozgur Yoruk| Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey, Fatma Ozabacigil Gur| Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey, Hamidullah Uyanik| Department of Microbiology, School of Medicine, Ataturk University, Erzurum, Turkey, Murat Yasar| Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey, Vahit Mutlu| Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey, Enver Altas| Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey, Elif Baysal| Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Gaziantep University, Gaziantep, Turkey, Seyithan Taysi| Department of Biochemistry and Clinical Biochemistry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Keywords
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- EP ID EP8737
- DOI 10.3889/MJMS.1857-5773.2010.0101
- Views 342
- Downloads 22
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