Antioxidant enzymosomes – properties and application
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
The application of catalase and superoxide dismutase in daily practice encounters many difficulties connected first of all with their loss of activity, and even with their degradation. Both enzymes, catalase and superoxide dismutase, practically do not penetrate biological membranes, which limits or even makes impossible their protective activity directed against ROS. However, the penetration of the membranous barrier becomes possible after the location of the enzymes in lipidic structures. One of the technologies of stabilization of the activity of enzymes consists in closing them in a liposome structure. The incorporation of the enzymes into a closed, such as liposome, structure or into their lipid bilayer screens and simultaneously protects them against degradation which they would undergo during use in the unshaded form. Concurrently it extends their half life and also increases their activity and stability. The structure in which an enzyme is enclosed in a liposome is called an enzymosome.
Authors and Affiliations
Magdalena Skólmowska, Marek Kmieć
Keywords
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