Resistance of Pseudomonas aeruginosa to antibiotics
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
The main problem in the treatment of nosocomial infections is the increasing drug resistance of microorganisms that cause them, limiting the number of effective antibiotics. Pseudomonas aeruginosa bacilli are the cause of many serious hospital-acquired infections occurring primarily in patients within high-risk groups. The most vulnerable are those with weakened immune systems, as well as those with extensive surgical wounds and burn wounds. Infections are usually of the nature of secondary infections, caused by multidrug strains. Due to the high antimicrobial activity, beta-lactams, aminoglycosides and quinolones are drugs commonly used in hospitals, both in prevention and treatment of infections with P. aeruginosa. However, their irrational use is associated with selection and spread of strains resistant to these antibiotics. Resistance of P. aeruginosa to antibiotics is the result of a number of independent co-occurring mechanisms. These are: reducing the membrane permeability, the efflux system, and production of enzymes inactivating and degrading antibiotics. The paper devotes special attention to the determination of resistance mechanisms responsible for this phenomenon.
Authors and Affiliations
Katarzyna Wolska, Barbara Kot, Małgorzata Piechota, Aneta Frankowska
Keywords
Related Articles
- EP ID EP67234
- DOI -
- Views 152
- Downloads 0
Leptin as a mediator between obesity and cardiac dysfunction
Obesity is now recognised as one of the most important risk factors for heart disease. Obese individuals have high circulating levels of leptin, a hormone secreted by adipose tissue and involved in energy homeostasis....
High doses of tocopherol in the prevention and potentiation of dioxin in experimental inflammation – potential application
Emission of toxic and persistent organochlorine compounds into the environment is known to have been recently a very important environmental and health problem. One of the major groups of these compounds is the polychl...
Treatment of problematic infantile hemangiomas with propranolol: a series of 40 cases and review of the literature
Infantile hemangiomas (IH) are neoplastic proliferations of endothelial cells which occur with an incidence of 10 to 12% within the first year of life. IH grow after birth and usually regress spontaneously, but still can...
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data
Introduction: Beta-galactosidase (GAL) is a lysosomal exoglycosidase involved in the catabolism of glycoconjugates through the sequential release of beta-linked terminal galactosyl residues. The stimulation of activity o...
The development of methods for obtaining monoclonal antibody-producing cells
Monoclonal antibodies (mAbs) are biomolecules of great scientific and practical significance. In contrast to polyclonal antibodies from immune sera, they are homogeneous and monospecific, since they are produced by hybri...