Antioxidant Status in Preeclampsia
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Aim of Study: To find out the activity of antioxidant status in preeclampsia. Methods: The study was conducted in the Dept. of Obstetrics and Gynecology in collaboration with Dept. of Biochemistry at Chandulal Chandrakar Memorial Medical College Kachandur, Durg (CG). Investigation was carried out in 50 women suffer from preeclampsia and compared with 50 normal control group composed of age matched healthy pregnant women. Results: The mean serum MDA levels were significantly higher in preeclampsia than that of normal pregnant women (p<0.001). Pre-eclampsia is characterized by increase blood pressure associated with proteinuria diagnosed usually in second and third trimester of pregnancy although exact etiology of the disease is not known but several researches have pointed toward it association with lipid peroxidation and endothelial cell dysfunction we have observed significant increase in MDA levels (a lipid peroxidation product) in pre-eclamptic women as compared to nonmotensive pregnant women Conclusion: Increased levels of oxidative stress markers and decreased levels of antioxidants in pre-eclamptic women suggest that oxidative stress markers play a significant role in the pathophysiology of pre-eclampsia. There is association of lipid peroxidation and preeclampsia. Deficiency of enzymatic antioxidants is also observed in women with preeclampsia. Oxidative markers and antioxidants serially throughout pregnancy may be able to substantiate the association of elevated lipid peroxidation and diminished antioxidant levels with preeclampsia.
Authors and Affiliations
Anjana Chaudhary, Rekha Ratnani, Monika Jindal
Keywords
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- EP ID EP540074
- DOI 10.21276/ijmrp.2018.4.2.068
- Views 86
- Downloads 0
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