Antiphospholipid Syndrome in Patient with Portal Venous Thrombosis: Case Report
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 2
Abstract
Antiphospholipid syndrome (APS) is defined by the presence of arterial and venous thrombosis, recurrent fetal death, cerebrovascular accidents, hemolytic anemia, thrombocytopenia and various manifestations on different organs in the presence of anticardiolipin antibodies (aCL) and or lupus anticoagulant (LA). It was reported in early 1980’s. This syndrome is the most common cause of acquired thrombophilia. There is no consensus for treatment among physicians. Overall there is a general agreement that patients with recurrent thrombotic episodes require life-long anticoagulation therapy and those with recurrent spontaneous abortions require anticoagulation therapy (low molecular weight heparin) and low dose aspirin during most of gestation. Immunosuppresion seems to be ineffective exept in patients with fulminate multiple organ failure i.e. catastrophic antiphospholipid syndrome where plasmapheresis can also be used. We present a case of 31 year old woman with primary APS and portal venous thrombosis (PVT), without any recognizable autoimmune disease. She has 4 spontaneous abortions, calf thrombosis, gangrene of one toe, refractory cutaneous ulcer on the heel and livedo reticularis. She is positive for aCL and LA, with hypergammaglobulinemia.
Authors and Affiliations
Ljubinka Damjanovska| University Rheumatology Clinic, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Ruse Rajcevski| General Hospital “8 of September”, Transfusiology, Skopje, Republic of Macedonia
Keywords
Related Articles
- EP ID EP8805
- DOI 10.3889/MJMS.1857-5773.2011.0178
- Views 323
- Downloads 15
Macedonian Medical Master of Science (MSc) Theses Defended in 2008
We present abstracts of MSc theses defended in 2008 at the Faculty of Medicine, University “Ss Kiril and Metodijâ€, Skopje, Republic of Macedonia. English summaries are published as they are translated by authors and...
The Role of Physical Agents in Treatment of Osteoporosis
Osteoporosis is a chronic, progressive disease, which represents a multifactorial condition. Treatment of patients with osteoporosis has several aspects that require a team approach. It consists of application of appro...
Histological Changes and Testicular Dysfunction in Severely Burned Rats
Background: The immediate and early sequelae of burns such as vascular collapse and wound sepsis have been extensively studied. Some studies now show that burns cause significant changes in most body systems including...
Aberrant Confluence of Intrahepatic Biliary Ducts - A Case Report
Aim: Besides the most frequent-modal type of confluent patterns intrahepatic biliary ducts, there are cases with aberrant type of confluence. The aim of this report is to present a case with aberrant confluence of intr...
Combination of Left Ventricular Noncompaction and Bicuspid Aortic Valve in 19-Year-Old Male: A Case Report from Republic of Macedonia
Background: Noncompaction of the ventricular myocardium is a rare, unclassified cardiomyopathy due to an arrest of myocardial morphogenesis. The characteristic echocardiographic findings consist of multiple, prominent...