Antiphospholipid Syndrome in Patient with Portal Venous Thrombosis: Case Report
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 2
Abstract
Antiphospholipid syndrome (APS) is defined by the presence of arterial and venous thrombosis, recurrent fetal death, cerebrovascular accidents, hemolytic anemia, thrombocytopenia and various manifestations on different organs in the presence of anticardiolipin antibodies (aCL) and or lupus anticoagulant (LA). It was reported in early 1980’s. This syndrome is the most common cause of acquired thrombophilia. There is no consensus for treatment among physicians. Overall there is a general agreement that patients with recurrent thrombotic episodes require life-long anticoagulation therapy and those with recurrent spontaneous abortions require anticoagulation therapy (low molecular weight heparin) and low dose aspirin during most of gestation. Immunosuppresion seems to be ineffective exept in patients with fulminate multiple organ failure i.e. catastrophic antiphospholipid syndrome where plasmapheresis can also be used. We present a case of 31 year old woman with primary APS and portal venous thrombosis (PVT), without any recognizable autoimmune disease. She has 4 spontaneous abortions, calf thrombosis, gangrene of one toe, refractory cutaneous ulcer on the heel and livedo reticularis. She is positive for aCL and LA, with hypergammaglobulinemia.
Authors and Affiliations
Ljubinka Damjanovska| University Rheumatology Clinic, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Ruse Rajcevski| General Hospital “8 of September”, Transfusiology, Skopje, Republic of Macedonia
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- EP ID EP8805
- DOI 10.3889/MJMS.1857-5773.2011.0178
- Views 348
- Downloads 15
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