Antiplasmodial Properties, Toxicity and Novelty-Induced Behavior of a Formulation from Picralima nitida and Alstonia boonei
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 8, Issue 2
Abstract
Aims: This study aimed at investigating the antiplasmodial activities of the combination of Alstonia boonei De Wild (Apocynaceae) stem-bark and Picralima nitida (Stapf) T.&H.Dur. (Apocynaceae) seed, which is currently being produced as MAMA Syrup (MS) for malaria treatment in Nigeria. The study has also provided information on the CNS and sub-chronic toxicity effects of MS. This is to justify the folkloric use of the mixture of the two plants as an antimalarial remedy as well as the safety of MS. Methodology: Swiss albino mice of both sexes, (18-22 g), were used for the antiplasmodial experiments with the freeze-dried extractive from the decoction of the 1:1 mixture of the two plants against chloroquine-sensitive Plasmodium berghei NK65 strain. For the toxicity and novelty-induced behavioral (NIB) studies, twenty four rats were divided into four groups (n=6 per group) for three dose (150, 300 and 600 mg/kg) levels of MS and the vehicle (distilled water). The NIB was observed on days 1 and 30 of administration of MS and the vehicle. The animals were sacrificed on day 30 and blood harvested for biochemical assays. Results: The results of the antiplasmodial investigation showed that 12.5 mg/kg extractive of the plant mixture gave antiplasmodial activity equivalent to 82% of the activity of chloroquine (5 mg/kg). The NIB results showed that acute oral administration of MS had no significant effects while the sub-chronic administration caused a significant (P<0.05) increase in rearing but decrease in grooming behaviours, dose-dependently. The biochemical parameters were not affected by the administration of MS at all doses used. Conclusion: The extractive of the plant mixture possessed antiplasmodial activity while the oral sub-chronic administration of MAMA Syrup had central excitatory effects but no significant toxicity potentials in rats.
Authors and Affiliations
A. T. Falodun, C. O. Ajayi, E. M. Obuotor, A. O. Adepiti, M. A. Akanmu, A. A. Elujoba
Keywords
Related Articles
- EP ID EP350260
- DOI 10.9734/EJMP/2015/17211
- Views 149
- Downloads 0
Organic Extracts of Pelargonium graveolens: Phenol Content, Anti-oxidant and Anti-bacterial Activities
Aims: The aim of this study was determination of antioxidant activity and total phenolic content and antibacterial activity of Pelargonium graveolens organic extracts. Study Design: Different methods implemented for isol...
Toxicity Studies on Anti-fungal Essential Oils Extracted from Selected Aromatic Plants from Mabira and Kakamega Forests, East Africa
Aim: In a bid to explore for grain bio-preservatives, essential oils extracted from Cymbopogon citratus, Rosmarinus officinalis, Monanthataxis littoralis and Aframomum angustifolium, that were earlier established to have...
Antibacterial Properties of the Leaf Extracts of Anthocleista djalonensis A. Chev on Some Pathogenic Organisms
Aims: To determine the antibacterial effect of methanol, petroleum ether and hot water extracts of Anthocleista djalonensis A. Chev on some pathogenic bacteria and to establish the use of the leaf extract in herbal medic...
Gastroprotective Effects of Masfon–Aloe vera Drink: Its Effects on Gastric Acid and Mucus
Masfon – Aloe vera drink was employed in this study to ascertain its effect on gastric acid secretion, mucus output and cytoprotection. The study utilized forty five (45) wistar albino rats which were divided into 3 batc...
Ginkgetin or Isoginkgetin: The Dimethylamentoflavone of Dioon edule Lindl. Leaves
Aims: Phytochemical study of the biflavonoid content of Dioon edule Lindl. leaves in addition to quantification of the phenolic content and evaluation of their antioxidant potential. Methodology: Chromatographic isolatio...