Antiplatelet effect of statins is augmented in diabetic rabbits.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 2
Abstract
The effects of various statins on platelet aggregation in blood samples from normal and diabetic rabbits were measured. All of the statins used in our study inhibited platelet aggregation by about 20% at 1 microM. Our results show that diabetes increased the rate of platelet aggregation from 48 +/- 5% to 72 +/- 8%, however, statins inhibited the rate of platelet aggregation by about 60% (p < 0.01). The addition of leptin (125 ng/ml) to blood samples from healthy rabbits increased the aggregation rate to about 64%, but statins decreased this rate to about 26%. Our results indicate that diabetes increases the rate of platelet aggregation in rabbits and increases antiplatelet efficacy of statins due to interactions with leptin.
Authors and Affiliations
Ivan Kocić, Beata Racek-Król, Iga Wapniarska, Izabela Rusiecka, Robert Wasilewski, Marcin Bitel
Keywords
Related Articles
- EP ID EP124010
- DOI -
- Views 79
- Downloads 0
Cytotoxic activity of the selected pyridinium salts against murine leukemia L1210.
The objective of this work was to evaluate the relationship between chemical reactivity of 3-substituted pyridinium salts and their cytotoxic properties against murine leukemia L1210. Chemical reactivity of pyridinium sa...
Can P-glycoprotein expression on malignant tumor tissues predict opioid transport at the blood-brain barrier in cancer patients?
Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents.
The effects of the sulfhydryl reducing agents 2-mercaptoethanol and dithiothreitol on wortmannin-induced inhibition of phosphoinositide 3-kinase (PI3K) were studied in order to examine whether the sulfhydryl reducing age...
Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes.
Backround: Lomefloxacin is a potent bactericidal antibiotic. The use of this drug in treatment of various infections is accompanied by serious adverse effects on pigmented tissues. The exact mechanisms of lomefloxacin si...
Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells.
The aim of the present study was to investigate the kinetics of the effects exerted by Temodal and quercetin on the survival of the human astrocytoma MOGGCCM cell line. Our results indicate that quercetin was toxic and i...