Antipyretic and antioxidant activities of Eleucine indica
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 4
Abstract
Eleucine indica is a medicinal plant used by the Ibibios of southern Nigeria in the treatment of malaria fever and also as a tonic. This study was to evaluate the antipyretic activities of the ethanol extract and the antioxidant activities of the extract, n-hexane, chloroform, ethyl acetate, butanol and aqueous fractions of the whole plant. Basal rectal temperatures of adult albino rats of both sexes were recorded and the animals fasted for 24 h but allowed access to water ad libitum. They were then treated with DNP (10 mg/kg) and amphetamine (5 mg/kg) intraperitoneally. Within 30 min following the administration of amphetamine, animals with increased temperature of 1◦C were selected and randomized into five groups of six animals each. Group 1 received 10 ml/kg of distilled water orally. Group’s 2 - 4 animals were administered 200 – 600 mg/kg of the extract intraperitoneally respectively. Group 5 animals received 100 mg/kg of acetyl salicylic acid orally. Yeast-induced pyrexia was achieved using 10 ml/kg of Brewer’s yeast suspension injected subcutaneously in the back below the neck. Rectal temperatures were then obtained at 0.5 h and thereafter hourly for 5h. Superoxide dismutase, reduced glutathione, catalase, free radical scavenging with 1, 2-diphenyl-2- picrylhydrazyl, lipid peroxidation and methaemoglobin were measured in rats using standard methods. The result showed a significant (p < 0.05 – 0.001) and dose-dependent reduction in the elevated body temperature in rats pre-treated with the extract compared to control. There were also significantly high levels of superoxide dismutase and increased levels of reduced glutathione, catalase, free radical scavenging activity with DPPH, lipid peroxidation and methaemoglobin in both serum samples and liver homogenates of rats relative to control. These results corroborate with the ethno botanical use of the plant as antipyretic and depicts that the plant has both antioxidant ad pro-oxidant properties.
Authors and Affiliations
Ette Okon Ettebong, Paul Alozie Nwafor
Keywords
Related Articles
- EP ID EP49647
- DOI -
- Views 169
- Downloads 0
Comparative effects of aqueuos extract of Phyllanthus amarus and its fractions on urinary excretion in rat
The aim of the present study was to compare the effect of Phyllanthus amarus extracts and its fractions on urinary excretion. Aqueous extract of Phyllanthus amarus was prepared by decoction of the whole plant and lyoph...
Evaluation of neuro-protective activity of Brihatvata Chinthamani Rasa
The objective of the study was to screen the neuroprotective role of Brihatvata Chinthamani Rasa, a compound mineral formulation extensively used in stroke condition in the Indian system of medicine. The selected anima...
Antidiabetic potential of Musa paradisiaca in Streptozotocin- induced diabetic rats
Aim: Over the last few decades the role of medicinal plants as a primary tool in the preservation of health and management of diseases is realized with great concern. This is mainly due to the use of synthetic drug mol...
Chlorpyrifos-induced oxidative stress in rat’s brain and protective effect of grape seed extract
Oxidative stress is one of the possible mechanisms resulted from chlorpyrifos toxicity. Therefore, the aim of this study is to evaluate the in vivo effects of chlorpyrifos (7.5 mg/kg, s.c., for 28 days, 1/10 LD50 of CP...
Evaluation of Salvia haematodes Linn for their antioxidant, anti-microbial, anti-lipoxygenase and anticholinesterase activity
The indigenous medicinal plant Salvia haematodes Linn (SAL) was screened for its pharmacological activities. The crude extract fractions were prepared in methanol, n-hexane, di chloromethane (DCM) and n-butanol by cold...