In vivo antidiabetic activity of aqueous and ethyl acetate leaf extract of Senna singuena (Delile) in alloxan induced diabetic mice
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 2
Abstract
The folkloric claims that Senna singuena confers antidiabetic effect to prescribed patients has received long term clinical application accompanied by limited scientific data in support of such claims. This study aimed at bioscreening for hypoglycemic activity of the aqueous and organic fractions of S. singuena in alloxan induced diabetic mice. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by graded doses of the aqueous and ethyl acetate leaf extract administered to the experimentally diabetic mice following an overnight fast. The composition of the various phytochemicals of the plant extract was quantitatively assessed using standard procedures. Oral and intraperitoneal administration of the aqueous and ethyl acetate leaf extract caused a significant reduction in plasma glucose level in a dose independent manner in both fractions. The hypoglycemic activity could be attributed to phytoconstituents found in the plant extract. The generated data supports the folkloric claims associating S. singuena with hypoglycemic effects. However, there is need for further studies on this plant to investigate the mechanism of its activity and determine its safety profiles in order to explore possibilities of developing a new antidiabetic drug.
Authors and Affiliations
Njogu M. Stephen, Arika M. Wycliffe, Machocho K. Alex, Ngeranwa J. N. Joseph, Njagi N. M. Eliud
Keywords
Related Articles
- EP ID EP49720
- DOI -
- Views 188
- Downloads 0
Phytochemical screening and cytotoxicity of selected plants used as anthelmintics in Loitoktok Sub-County, Kenya
The practice of traditional medicine is as old as the human race, and plants are an important source of research and development of new drugs. Anthelmintic resistance in human and animal pathogenic helminthes has been...
Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent
The leaves of Newbouldia laevis is traditionally used to treat diabetes mellitus in southeast Nigeria. The apigenin isolated from the methanol fraction of dichloromethane/methanol (1:1) extract of the leaves was evalua...
Quality control constraint of Guizotia abyssinica Cass, source of medicinally useful edible oil seeds
Introduction: Guizotia abyssinica Cass. branched herb with erect, stout stem, commonly known as Ramtil or Niger seed. Seeds are the rich source of oil with high nutritional index. Traditionally the seed powder is used a...
Phytochemical profile and antimicrobial potential of methanolic extracts of bark and leaf of Quassia indica (Gaertn.) Nooteb
The study comprises the results of phytochemical analysis and antimicrobial evaluation of extracts from bark and leaf of Quassia indica (Gaertn). Nooteb. – a medicinal plant used in traditional healing owing to its ana...
The Effects of Probiotics Supplementation on Milk Yield and Composition of Lactating Dairy Cows
The effects of microbials dietary supplements on performances and health of the animals, in recent is becoming very critical. Consequently, direct-feds microbials (DFM), is an area of interest of several authors, since...