Antitumor activity of Annona muricata L. fruit and leaves in Ehrlich’s ascites carcinoma cell- treated mice
Journal Title: International Journal of Advanced Biochemistry Research - Year 2018, Vol 2, Issue 1
Abstract
Purpose: The main goal of this study was aimed to evaluate the antitumor effect of A. muricata extract of both leaves and fruit in EAC-bearing mice model in comparison with a standard therapeutic agent, cisplatin. Methods: The antitumor activity of the ethanol extracts of Annona muricata were evaluated against Ehrlich ascites carcinoma (EAC) tumor in mice at dose of 200mg/kg body weight orally. Mice were divided into five groups. Group I: (Normal group) mice were received (0.2 ml Saline), Group II: (Cancer group) 20 mice were intraperitoneally received EAC cells (2×106cells/mouse I.P.), Group III: (EAC + leaves extract) 20 mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group IV: (EAC + fruit extract) mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group V: (EAC+ cisplatin), 20 mice were intraperitoneally treated with cisplatin after 48 hours from injection with EAC at a daily dose of 2 mg/kg body weight for 9 consecutive days. Total experimental period was 11 days, after 24 h from the last dose, 8 mice in each group were anesthetized by diethyl ether and sacrificed for the histopathological examination of Kidney tissue. Results: Administration of the extracts resulted in that A. muricata has protective role on the management of histopathological changes occurred in cancer induced mice. Conclusion: The results suggest that the ethanol extract of Annona muricata L. Leaves and fruit showed anticancer effect when compared to the tumor group.
Authors and Affiliations
Lames M- Othman, Ahmed K- Hassan, Atef E-Abd Elbaky, Mohamed A- Mahmoud
Keywords
Related Articles
- EP ID EP529377
- DOI -
- Views 60
- Downloads 0
Evaluated some of side effects of methotrexate's administration through Freund's complete adjuvant induced arthritis in rat model
The present study aimed to evaluate some of side effects of methotrexate adminstration (MTX) in the treatment of complete Freund’s adjuvant (CFA) induced arthritis. Thirty Wistar male rats weighing 180-200 g were divided...
Human chorionic gonadotropin levels as a biochemical markers in pregnancy induced hypertension
Pregnancy Induced Hypertension and its sequel are severe complications of pregnancy. The prognostic significance of high levels of serum free β-hCG in early pregnancy for subsequent obstetric and perinatal risks is still...
Biomarkers to assess chronic alcohol consumption: carbohydrate deficient transferrin (CDT) a reliable biomarker
Alcohol abuse is very common all over the world. The biological, clinical and social effects of alcohol abuse have long made evident the need for objective and specific markers for alcohol-related diseases and for early...
Evaluation of effect of Trema guineensis extracts on serum concentrations of vitamins A, D and E during CCl4 induced hepatotoxicity in rat
The present study investigated the preventive effect of Trema guineensis on serum concentrations of vitamins A, D and E during hepatotoxicity in rat. The leaves of Trema guineensis collected from Abobo in the district of...
Synthesis of cinnamyl alcohol acetate in a static lipase bioreactor at room temperature
To make the synthesis of cinnamyl acetate not only green but also low energy consumption, absorbent cotton was taken as an immobilized material to prepare the immobilized Pseudomonas fluorescens lipase in a column glass...