Evaluation of effect of Trema guineensis extracts on serum concentrations of vitamins A, D and E during CCl4 induced hepatotoxicity in rat
Journal Title: International Journal of Advanced Biochemistry Research - Year 2018, Vol 2, Issue 1
Abstract
The present study investigated the preventive effect of Trema guineensis on serum concentrations of vitamins A, D and E during hepatotoxicity in rat. The leaves of Trema guineensis collected from Abobo in the district of Abidjan were used for the preparation of the aqueous extract by decoction and ethanolic extract by maceration. Then, healthy adult Wistar albino rats were used for the experimentation. The animals were pretreated with the extracts at the doses of 100 and 200 mg/kg of body weight by oral route one hour before CCl4 intraperitoneal injection for seven days. The administration of CCl4 resulted in a significant decrease of vitamins A, D and E rates in the serum while the pretreatment by the extracts increased the concentrations of these vitamins. The extracts of Trema guineensis would prevent vitamins A, D and E deficiency in serum due to hepatic injury.
Authors and Affiliations
Droucoula Guillaume Cyril, Okpekon Aboua Timothée, Séri Kipré Laurent, Tra Bi Irié Otis, Tchimon Dahno Perrine, Yapi Houphouët
Chemical composition of Lawsonia inermis cultivated under Sudanese conditions-existence of chemotypes species
Objectives: The objectives of this study are to: (i) qualitatively and quantitatively assessing the chemical components of Lawsonia inermis Leaves from cultivated plants in two localities in Central Sudan, and (ii) to id...
Evaluation of effect of Trema guineensis extracts on serum concentrations of vitamins A, D and E during CCl4 induced hepatotoxicity in rat
The present study investigated the preventive effect of Trema guineensis on serum concentrations of vitamins A, D and E during hepatotoxicity in rat. The leaves of Trema guineensis collected from Abobo in the district of...
Evaluated some of side effects of methotrexate's administration through Freund's complete adjuvant induced arthritis in rat model
The present study aimed to evaluate some of side effects of methotrexate adminstration (MTX) in the treatment of complete Freund’s adjuvant (CFA) induced arthritis. Thirty Wistar male rats weighing 180-200 g were divided...
Inflammatory markers in essential hypertension
Hypertension (HTN) is now a major health problem in India. Both environmental and genetic factors may contribute to regional and racial variations of blood pressure (B.P.) and hypertension prevalence. Obesity and weight...
A study on Multi Site phase catalysts and their characterization
A suitable catalyst is required to execute the phase-transfer reaction. There are mainly three factors which are responsible for the phase-transfer reactions. First is that the catalyst should be capable of transferring...