ANTITUMOR ACTIVITY OF BERBERINE AGAINST BREAST CANCER: A REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 2
Abstract
As the prevalence of breast cancer has been increasing day by day in almost every part of the world, there is need to develop alternative therapeutic measures for breast cancer control. To fulfill this need, chemoprevention is a novel approach. Efforts have been made to identify synthetic or natural products that can prevent the pre-neoplastic events preceding the occurrence of detectable cancer. Berberine (quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids) is one such compound. In this review in vitro and in vivo anticancer activities of berberine have been summarized. The mechanisms of action of berberine include; inhibition of tumorigenic microorganisms, regulation of oncogene, interaction with DNA and RNA, inhibition of carcinogenesis related enzymes and induction of apoptosis. Berbrine has synergistic activity of when given in combined medication while it is also responsible for reduction of multidrug resistance in breast cancer treatment.
Authors and Affiliations
Ahmad Raza, Bilal Aslam, Muhammad Naseer, Asghar Ali, Wafa Majeed, Shamshad-Ul- Hassan
Keywords
Related Articles
- EP ID EP153112
- DOI 10.7897/2230-8407.06219
- Views 66
- Downloads 0
IN VIVO EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SOLID DISPERSIONS OF GLIBENCLAMIDE USING PREGELATINISED STARCH AS A SOLUBILITY ENHANCER
Current study was undertaken to investigate the aptness of pregelatinised starch to get better solubility and In vitro dissolution rate of the poorly water soluble drug glibenclamide. Physical mixtures, kneading mixtures...
ANTIDIABETIC DRUGS IN AYURVEDA
Ayurveda the Indian traditional Medical science uses many drugs for diseases derived from medicinal plants, Minerals, herbo mineral. Diabetes (Madhumeha) is an important human ailment afflicting many from various walks o...
PROTECTIVE EFFECT OF ROOT EXTRACT OF NOTHOSAERVA BRACHIATA WIGHT IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS
In India, Berginia ligulata, Family Saxifragaceae is accepted source of ayurvedic drug Pashanabheda. Another species belong to Pashanabheda class is Nothosaerva brachiata Wight. The effect of oral administration of aqueo...
SWINE FLU (H1N1) VIRUS, PREVENTION AND THEIR TREATMENT: A REVIEW
Swine flu has been confirmed in a number of countries and it is spreading from human to human, which could lead to what is referred to as a pandemic flu outbreak. Pandemic flu is different from ordinary flu because it’s...
AYURVEDIC HERBAL DRUGS IN THE MANAGEMENT OF RECURRENT UTI IN PEDIATRICS
Urinary tract infection (UTI) is a common bacterial infection encountered in pediatric age group. The incidence varies with age, being more prevalent among boys during infancy and later on in girls. It generally resolves...